Application of super-resolution track-density technique: Earlier detection of aging-related subtle alterations than morphological changes in corpus callosum from normal population?

Journal of Magnetic Resonance Imaging : JMRI
Dan WangYue-Hua Li

Abstract

There are rare quantitative fiber density measurement techniques based on voxel measure changes of each corpus callosum (CC) subsegment with age. To observe the regularity of corpus callosum development in normal aging from subvoxel to macroscopic volume. Retrospective. In all, 131 healthy volunteers divided into six age groups. 3T MR with 32-channel head coil T1 -3D and diffusion-weighted imaging with six b-values in a 30 directions sequence. Track-density imaging (TDI) was used to visualize the complexity and the differences occurring in corpus callosum (CC) with age. TDI were reconstructed with a higher spatial voxel resolution of 0.1 mm subvoxel; TDI values are recognized as a subvoxel metric of real tract density. We reconstructed track density maps by using probabilistic streamline tractography combined with constrained spherical deconvolution. The CC was segmented into five subregions, and TDI, volume, and fractional anisotropy (FA) of each subregion in all the groups were measured using T1 W-3D images and compared. Polynomial regression was done to between age and (CC1, CC2, CC3, CC4, CC5) of TDI/volume/FA. Multiple comparisons test two-way analysis of variance (ANOVA) were used to compare the differences between differ...Continue Reading

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Citations

Apr 8, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Brian C Clark, Richard G Carson

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