Application of Synovex-H in veal calves: steroid release and residues

Food Additives and Contaminants
H H MeyerH Karg

Abstract

Four experiments were carried out with veal calves which were implanted subcutaneously with Synovex-H. Testosterone in blood plasma and also total oestrogens in plasma, urine and faeces during the trial and in liver, kidney and muscle after slaughter (62-75 days after implantation) were determined. Prepurification methods and radioimmunoassays for faeces and tissue samples were elaborated and validated. Variables between or within the trials were the sex, the dose (four pellets versus eight pellets; 25 mg testosterone propionate + 2.5 mg 17 beta-oestradiol-3-benzoate per pellet) and the implantation site (either on the base of the ear or on the middle of the pinna). Results from the blood plasma and the excreta showed that using four pellets implanted in the middle of the pinna guaranteed a continuous release in order that oestrogen levels were maximally doubled in comparison to controls. On the other hand, application of the same dose at the base of the ear was characterized by an accentuated burst during the first three days (10-fold elevation over controls). In plasma and excreta of male controls, higher oestrogen concentrations were measured as compared to the corresponding substrates of females. Comparing all groups, untre...Continue Reading

References

Sep 1, 1977·Journal of Animal Science·D M Henricks, A K Torrence
Sep 1, 1977·Journal of Animal Science·T G DunnG D Niswender
Jan 1, 1973·Journal of Steroid Biochemistry·R HähnelT Ratajczak
Jul 1, 1974·The Journal of Clinical Endocrinology and Metabolism·K AngsusinghaF H Taylor
Oct 1, 1968·The Journal of Clinical Endocrinology and Metabolism·D RodbardG T Ross
May 1, 1966·The Journal of Clinical Endocrinology and Metabolism·H Breuer, E Schott
Oct 26, 1957·Nature·W VELLE

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Citations

Apr 12, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·D MaumeF André

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