Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

Clinical and Translational Allergy
Jolanda H M van BilsenErwin L Roggen

Abstract

The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for prediction of the risk for food allergy development and the severity of the reaction are not sufficient. There is a substantial body of in vivo and in vitro data describing molecular and cellular events potentially involved in food sensitization. However, these events have not been organized in a sequence of related events that is plausible to result in sensitization, and useful to challenge current hypotheses. The aim of this manuscript was to collect and structure the current mechanistic understanding of sensitization induction to food proteins by applying the concept of adverse outcome pathway (AOP). The proposed AOP for food sensitization is based on information on molecular and cellular mechanisms and pathways evidenced to be involved in sensitization by food and food proteins and uses the AOPs for chemical skin sensitization and respiratory sensitization induction as templates. Available mechanistic data on protein res...Continue Reading

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Citations

Oct 7, 2018·Current Allergy and Asthma Reports·Rodrigo Jiménez-Saiz, Sarita U Patil
Aug 25, 2020·International Journal of Environmental Research·Walter Gottlieb Land
May 21, 2020·Frontiers in Immunology·Tamara HoppenbrouwersHarry J Wichers
Dec 10, 2019·Journal of Agricultural and Food Chemistry·Clélia VilleminGrégory Bouchaud

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