Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity.

Environmental Pollution
Francisco Inesta-VaqueraC Roland Wolf

Abstract

Inorganic arsenic (iAs) is a naturally occurring metalloid present in drinking water and polluted air exposing millions of people globally. Epidemiological studies have linked iAs exposure to the development of numerous diseases including cognitive impairment, cardiovascular failure and cancer. Despite intense research, an effective therapy for chronic arsenicosis has yet to be developed. Laboratory studies have been of great benefit in establishing the pathways involved in iAs toxicity and providing insights into its mechanism of action. However, the in vivo analysis of arsenic toxicity mechanisms has been difficult by the lack of reliable in vivo biomarkers of iAs's effects. To address this issue we have applied the use of our recently developed stress reporter models to study iAs toxicity. The reporter mice Hmox1 (oxidative stress/inflammation; HOTT) and p21 (DNA damage) were exposed to iAs at acute and chronic, environmentally relevant, doses. We observed induction of the oxidative stress reporters in several cell types and tissues, which was largely dependent on the activation of transcription factor NRF2. We propose that our HOTT reporter model can be used as a surrogate biomarker of iAs-induced oxidative stress, and it c...Continue Reading

References

Dec 10, 1998·The American Journal of Pathology·D R GermolecM I Luster
Aug 10, 2000·Journal of Toxicology. Clinical Toxicology·A SantraD N Mazumder
Oct 17, 2001·Toxicology and Applied Pharmacology·D J ThomasS Lin
Jun 22, 2002·Toxicology Letters·Jian Ping WangJack C Ng
Oct 5, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Wenbin MaLaura Schmidt
Mar 26, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Ken ItohMasayuki Yamamoto
May 3, 2003·Free Radical Biology & Medicine·Aki HirayamaAkio Koyama
Sep 19, 2003·Toxicology and Applied Pharmacology·Michael F HughesDavid J Thomas
Jul 28, 2004·Toxicology and Applied Pharmacology·Michael P WaalkesBhalchandra A Diwan
Feb 16, 2006·Journal of Epidemiology and Community Health·Mahfuzar RahmanLars Ake Persson
Mar 18, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xing CuiSeishiro Hirano
Sep 23, 2006·American Journal of Respiratory Cell and Molecular Biology·Jawed Alam, Julia L Cook
Oct 5, 2006·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Simon KapajProsun Bhattacharya
Mar 8, 2008·Toxicology and Applied Pharmacology·Gensheng Wang, Bruce A Fowler
Jul 22, 2008·Toxicology and Applied Pharmacology·Yuanyuan XuGuifan Sun
May 7, 2009·The Lancet Oncology·Kurt StraifUNKNOWN WHO International Agency for Research on Cancer Monograph Working Group
Jun 23, 2009·Toxicology and Applied Pharmacology·Tao JiangDonna D Zhang
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jennifer M CarbreyRita Mukhopadhyay
Oct 17, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·David J ThomasH Rex Gaskins
Jun 2, 2010·Epigenomics·John F Reichard, Alvaro Puga
Jul 21, 2010·Biochemical and Biophysical Research Communications·Francisco A Iñesta-VaqueraAna Cuenda
Oct 13, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Erik J TokarMichael P Waalkes
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael McMahonJohn D Hayes
Jun 21, 2011·Environmental Health Perspectives·J Christopher StatesR Clark Lantz
Feb 23, 2012·Scientific Reports·Daisuke OikawaTakao Iwawaki
May 4, 2012·Environmental Health : a Global Access Science Source·Ponpat IntarasunanontMathuros Ruchirawat
Jun 14, 2012·PloS One·Courtney D Kozul-HorvathJoshua W Hamilton
Nov 29, 2012·Journal of Biochemical and Molecular Toxicology·Alexandria LauDonna D Zhang
Apr 17, 2013·Molecular and Cellular Biology·Alexandria LauDonna D Zhang
Jun 18, 2014·Cancer Research·Colin J HendersonC Roland Wolf
Aug 5, 2015·Regulatory Toxicology and Pharmacology : RTP·Michael R GarryJohn M DeSesso
Oct 17, 2015·International Journal of Environmental Research and Public Health·Jinlong LiBing Li
Nov 26, 2015·Environmental Toxicology and Pharmacology·Nafiseh Sadat AlamolhodaeiGholamreza Karimi
Aug 9, 2016·Biological Trace Element Research·Mengchuan XuMingxia Jing
Aug 24, 2016·Environmental Pollution·Zhiling GuoGuibin Jiang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.