Application of the IWG-2 Diagnostic Criteria for Alzheimer's Disease to the ADNI

Journal of Alzheimer's Disease : JAD
Hui-Fu WangAlzheimer’s Disease Neuroimaging Initiative

Abstract

The International Working Group (IWG) recently proposed the revised diagnostic criteria for Alzheimer's disease (AD) to define and refine several types of AD, and to reclassify AD-related biomarkers into diagnostic and progression markers, but its performance is not known. This study was designed to describe the application of the revised IWG criteria in the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, and to ascertain whether diagnostic and progression markers show significant differences in their relationships to AD severity and progression. Based on the requirements of the refined criteria, 857 ADNI subjects with memory evaluation and at least one pathophysiological marker (CSF or amyloid imaging biomarkers) were eligible and reclassified in this study, and we calculated the associations of diagnostic (CSF and amyloid PET) and progression markers (MRI and fluorodeoxyglucose-PET) with AD severity and progression respectively. The majority (84.2% ) of ADNI AD group (n = 117) and 173 MCI (37.4% ) subjects in ADNI met the definition of typical AD; and 105 cognitively normal (41.0% ) individuals were diagnosed as asymptomatic AD. Furthermore, diagnostic and progression markers showed significant differences when co...Continue Reading

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Citations

Jan 7, 2017·Journal of Alzheimer's Disease : JAD·Linda J C van Waalwijk van DoornMarcel M Verbeek
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May 19, 2020·Aging·Mei XueUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Aug 15, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Hui-Fu WangUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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