Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: EXAMPLE: acrylamide (CAS No. 79-06-1)

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
P Michael BolgerR Woodrow Setzer

Abstract

Acrylamide (CH(2)CHCONH(2), CAS Registry No. 79-06-1) is an industrial chemical used since the 1950s as a chemical intermediate in the production of polyacrylamides, which are used as flocculants for clarifying drinking-water and other industrial applications. The neurotoxicity of acrylamide in humans is well known from occupational and accidental exposures. In addition, experimental studies with acrylamide in animals have shown reproductive, genotoxic and carcinogenic properties. Acrylamide may be formed when foods, particularly those that are high in carbohydrates and low in protein, are subjected to high temperatures during cooking or other thermal processing.

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Citations

Dec 3, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Joanna WykaJadwiga Biernat
Apr 18, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Marta Mesías, Francisco J Morales
Apr 2, 2015·Journal of Exposure Science & Environmental Epidemiology·Hanna MojskaWłodzimierz Sawicki
Sep 13, 2011·Nutrition·Wanda Furmaga-JablonskaRyszard Pluta
Jan 14, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Véronique SirotJean-Charles Leblanc
Mar 16, 2017·Journal of the Science of Food and Agriculture·Mahmoud M El TawilaAbdulateef A Neamatallah
Mar 31, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marco J ZeilmakerWout Slob
Nov 21, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Marta MesiasFrancisco J Morales
Nov 6, 2010·Journal of Agricultural and Food Chemistry·Jingsong YeCaius M Rommens

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