Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: aflatoxin B1 (AFB1)

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Diane BenfordR Woodrow Setzer

Abstract

Aflatoxin B1 (AFB1) has been consistently shown to be a potent mutagen and is a liver carcinogen in humans and a wide range of animal species. The Fisher rat appears to be the most sensitive animal model. Dose-response modelling results in a BMDL(10) of 250 ng/kg-bw/d. Estimates of mean dietary exposure estimates were 0.4 ng/kg-bw/d and 2.6 ng/kg-bw/d, representing regions with low and high exposure, respectively. The MOEs for mean exposure therefore range from 100 to 600.

References

Apr 1, 1979·Food and Cosmetics Toxicology·F W Carlborg
Feb 15, 1976·International Journal of Cancer. Journal International Du Cancer·F G PeersC A Linsell
Oct 1, 1974·Food and Cosmetics Toxicology·G N WoganP M Newberne

❮ Previous
Next ❯

Citations

Aug 1, 2011·Mycotoxin Research·Amin Osman ElzupirAbdelrahim M Elhussein
Aug 1, 2011·Mycotoxin Research·Yin-Hui LeongNurul Izzah Ahmad
Aug 21, 2014·International Journal of Environmental Research and Public Health·Xi PengKejie Chen
Jul 4, 2012·Toxicology·Jente BoonenBart De Spiegeleer
Sep 20, 2015·Toxicon : Official Journal of the International Society on Toxinology·Caixia LiuQing Wang
Jan 24, 2017·Food Additives & Contaminants. Part B, Surveillance·Ljilja TorovićMilka Popović
May 17, 2017·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Gisela H Degen
Sep 12, 2012·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·P D AndradeE D Caldas
Jun 17, 2020·Archives of Toxicology·Andrea HartwigGerhard Eisenbrand
May 20, 2011·Critical Reviews in Toxicology·Susan P FelterGary M Williams
Jul 25, 2020·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Armel Elysée YapoMarina Koussémon
Jun 11, 2020·Food Research International·Carolina Fernanda S C CoppaCarlos A F Oliveira
Mar 31, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Larissa T FrancoCarlos A F Oliveira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Benjamin SmithR Woodrow Setzer
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
A G RenwickR Woodrow Setzer
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Gary WilliamsR Woodrow Setzer
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Benjamin SmithR Woodrow Setzer
© 2021 Meta ULC. All rights reserved