Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: benzene, CAS: 71-43-2

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Benjamin SmithR Woodrow Setzer

Abstract

The role of genotoxic events in the aetiology of benzene induced tumours cannot be ruled out. Dose response modelling of the data for benzene gave a BMDL10 for female Zymbal gland carcinoma of 17.6 mg/kg-bw/d following adjustment to daily average doses. The MOEs ranged from 2 x 10(6) to 0.4 x 10(6) depending on the assumptions used in the exposure estimation.

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Citations

May 8, 2010·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·K E Appel, K Abraham
Aug 1, 2011·Mycotoxin Research·Yin-Hui LeongNurul Izzah Ahmad
Feb 24, 2016·International Journal of Food Science·Vânia Paula Salviano Dos SantosKaren Signori Pereira

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