Application of the micronucleus test to exfoliated epithelial cells from the oral cavity of beedi smokers, a high-risk group for oral cancer

Mutation Research
S SuhasC Ramesh

Abstract

The primary sites for occurrence of oral cancer include the buccal mucosa, tongue, alveolus, palate, lip and the floor of the mouth. In this study, an attempt was made to estimate the cytogenetic damage in different regions of the oral mucosa in people habituated to smoking beedi,which is one of the major forms of tobacco consumption in India and believed to be a major risk factor for oral cancer. By using the micronucleus assay on exfoliated cells from the buccal mucosa, palate and tongue of beedi smokers, we examined an early cellular response to the effect of beedi smoking. A total number of 50 randomly selected male subjects were included in the study. Case and control groups (smokers and non-smokers, respectively) comprised 25 subjects each. The difference in mean micronucleated cell count between cases and controls was significant (P <0.01) for buccal mucosa and palate, but not for tongue. The correlation between age and micronucleus cell count was weak for both cases (r=0.27) and controls (r=0.36).

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Citations

Sep 26, 2009·Toxicology Mechanisms and Methods·Sumana ChatterjeeSila Chakrabarti
Feb 18, 2016·Journal of Cancer Research and Therapeutics·Rashmi MetgudSahul Lerra
Apr 4, 2015·Human & Experimental Toxicology·L P WebberV C Carrard
Nov 21, 2017·Environmental Science and Pollution Research International·Marcelino Benvindo-SouzaLia Raquel de Souza Santos
Feb 26, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sharen Huang, Hsueh-Erh Liu
Jul 15, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Ramkrishna BhalchandraMammen Chandy
Nov 22, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ebru Derici EkerSema Altan Akgül
Sep 28, 2017·Environmental Monitoring and Assessment·B C Gómez-MedaM G Sánchez-Parada
Apr 29, 2020·Animals : an Open Access Journal From MDPI·Eduardo Naranjo-VázquezGuillermo Moisés Zúñiga-González
Oct 7, 2006·The American Journal of Clinical Nutrition·Armen K Nersesyan
Aug 19, 2021·Clinical Oral Investigations·Rodrigo Rohenkohl SilvaPaula Benetti

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