PMID: 9647303Jul 1, 1998Paper

Application of the MRC brain tumour prognostic index to patients with malignant glioma not managed in randomised control trial

Journal of Neurology, Neurosurgery, and Psychiatry
A Z LatifI R Whittle

Abstract

The MRC brain tumour prognostic index, which uses clinical variables to place patients in different outcome categories, has not been evaluated on a cohort outside a randomised controlled trial. The aims of this study were to (a) determine in a large cohort of patients, derived solely from one centre and not in a clinical trial, whether the MRC prognostic index stratified patients for outcome; (b) compare actual outcomes with those obtained in the original studies; and (c) examine whether neuropathological diagnosis was an independent prognostic variable. The MRC prognostic index was calculated for 236 patients with either glioblastoma or anaplastic astrocytoma managed at a dedicated neuro-oncology clinic in Edinburgh between 1989 and 1995. For this mixed population of malignant glioma the median survival was 8.6 months. Two year survival was 72.2% for patients with an MRC index score of 1-10; 36.3% for those with an index score of 11-15; 25.1% for those scoring 16-20; 20.4% with those scoring 21-25; 4.8% with those scoring 26-33; and 0% for those scoring 34-38. Exclusion of 79 patients who would not have been eligible for the MRC studies from which the index was derived, because they were either too old or did not receive radio...Continue Reading

References

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Citations

Apr 2, 2004·American Journal of Clinical Oncology·Branislav JeremicNebojsa Nikolic
May 20, 2014·Journal of Neuro-oncology·Ruth F DeightonIan R Whittle
Jan 2, 2016·Journal of Neurosurgery·Pratipal Kalsi, Nitin Mukerji
Nov 17, 2009·European Journal of Cancer Care·A M StarkH M Mehdorn
Jun 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·René-Olivier MirimanoffRoger Stupp
Jun 24, 2008·British Journal of Neurosurgery·E AndersonI R Whittle
Jun 29, 2018·Expert Opinion on Therapeutic Patents·Matthew HarrisDavid Bailey
Nov 19, 2019·Acta neurochirurgica·Johannes DietterleJürgen Meixensberger
Feb 6, 2003·Anti-cancer Drugs·Maria PiribauerChristine Marosi

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