Application of the Sampson equation to estimate LDL-C in children: Comparison with LDL direct measurement and Friedewald equation in the BLIP study.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
Arrigo F G CiceroBLIP Study group

Abstract

In epidemiological trials and in clinical practices, it is relevant to have affordable and reliable methods to measure the main lipid cardiovascular risk factors, and in particular low-density lipoprotein cholesterol (LDL-C) plasma level. In this context, we aimed to compare the reliability of the Friedewald's (LDL-Cf) and Sampson's (LDL-Cs) equations with the LDL-value dosed by a validated dosage method (LDL-Cd) in a large cohort of children. We considered the lipid values of 145 infants, 278 preschoolers, 810 scholar children, and 1372 adolescents (Total N. 2605, 1291 males, 1314 females), with mean total cholesterol (TC) = 169.8 ± 39.7 mg/dL, HDL-Cholesterol = 50.8 ± 12.7 mg/dL, non HDL-Cholesterol = 118.9 ± 35.9 mg/dL, Triglycerides (TG) = 90.3 ± 77.9 mg/dL, LDL-Cd = 106.2 ± 29.9 mg/dL, LDL-Cf = 100.9 ± 33.8 mg/dL, and LDL-Cs = 102.2 ± 33.4 mg/dL. Comparing the distance to the LDL-Cd, Friedewald's equation mildly but significantly underestimated in infants (3.4 ± 5.3 mg/dL), preschoolers (1.5 ± 7.1 mg/dL). Children (1.2 ± 2.2 mg/dL) and adolescents (1.1 ± 5.9 mg/dL) compared to Sampson's equation (all comparisons, p < 0.001). Our analysis, being carried out on a large population sample, shows that Sampson's equation is more...Continue Reading

References

Aug 10, 2018·Current Cardiology Reports·Albert Wiegman
Sep 27, 2018·Journal of Clinical Lipidology·Piers BlackettDon P Wilson
Apr 7, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Arrigo F G CiceroUNKNOWN Brisighella Heart Study group
Jul 3, 2020·Journal of Atherosclerosis and Thrombosis·Barak ZafrirMoshe Y Flugelman
Sep 27, 2020·European Journal of Internal Medicine·Federica PianiUNKNOWN BLIP Study group

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