Application of the Tissue Composition-Based Model to Minipig for Predicting the Volume of Distribution at Steady State and Dermis-to-Plasma Partition Coefficients of Drugs Used in the Physiologically Based Pharmacokinetics Model in Dermatology

Journal of Pharmaceutical Sciences
Patrick PoulinClaire E Wilson

Abstract

The minipig continues to build a reputation as a viable alternative large animal model to predict humans in dermatology and toxicology studies. Therefore, it is essential to describe and predict the pharmacokinetics in that species to speed up the clinical candidate selection. Essential input parameters in whole-body physiologically based pharmacokinetic models are the tissue-to-plasma partition coefficients and the resulting volume of distribution at steady-state (Vss). Mechanistic in vitro- and in silico-based models used for predicting these parameters of tissue distribution of drugs refer to the tissue composition-based model (TCM). Robust TCMs were initially developed for some preclinical species (e.g., rat and dog) and human; however, there is currently no model available for the minipig. Therefore, the objective of this present study was to develop a TCM for the minipig and to estimate the corresponding tissue composition data. Drug partitioning into the tissues was predominantly governed by lipid and protein binding effects in addition to drug solubilization and pH gradient effects in the aqueous phase on both sides of the biological membranes; however, some more complex tissue distribution processes such as drug bindin...Continue Reading

References

Jun 1, 1979·The Journal of Physiology·D K Harrison, W F Walker
Oct 1, 1979·The Journal of Investigative Dermatology·B J VermeerC M van Gent
Jun 1, 1992·Journal of Animal Science·Y GuT G Martin
Sep 1, 1986·Microvascular Research·J L BertJ M Mathieson
Jan 1, 1983·British Journal of Clinical Pharmacology·M Gerecke
Jan 10, 2002·Journal of Pharmaceutical Sciences·Patrick Poulin, Frank-Peter Theil
Nov 5, 2002·Biopharmaceutics & Drug Disposition·J Cory Kalvass, Tristan S Maurer
Apr 29, 2005·Journal of Pharmaceutical Sciences·Trudy RodgersMalcolm Rowland
Mar 7, 2006·Journal of Biochemical and Biophysical Methods·Yufen ZhangStefan Balaz
Mar 21, 2007·Pharmaceutical Research·Trudy Rodgers, Malcolm Rowland
Nov 6, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Walter Schmitt
Oct 3, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Loren M BerryMin-Hwa Jasmine Lin
Jul 14, 2010·Journal of Pharmacological and Toxicological Methods·Lars EllegaardUNKNOWN Steering Group of the RETHINK Project
Aug 6, 2010·Journal of Pharmacological and Toxicological Methods·Gerd BodeUNKNOWN Steering Group of the RETHINK Project
Sep 28, 2010·Toxicology and Applied Pharmacology·Thomas PeyretKannan Krishnan
May 17, 2011·Journal of Pharmaceutical Sciences·Patrick Poulin, Sami Haddad
Feb 9, 2012·The Journal of Pharmacy and Pharmacology·Helen GrahamLeon Aarons
Sep 11, 2012·Journal of Pharmaceutical Sciences·Trudy RodgersMalcolm Rowland
Nov 28, 2012·Pharmaceutical Research·Claudia Suenderhauf, Neil Parrott
Jan 15, 2014·The Journal of Physical Chemistry. B·Markéta PaloncýováMichal Otyepka
Nov 20, 2014·Pharmaceutical Research·Longjian ChenGuoping Lian
Mar 4, 2015·Journal of Medicinal Chemistry·Brett R BenoNicholas A Meanwell
Dec 22, 2015·Journal of Pharmacokinetics and Pharmacodynamics·Els Van PeerSteven Van Cruchten
Jan 19, 2016·Drug Metabolism and Pharmacokinetics·Hiromichi YoshimatsuShinji Yamashita
May 11, 2016·Cutaneous and Ocular Toxicology·Alain Stricker-KrongradGuy Bouchard
Mar 11, 2017·Scientific Reports·Magdalena VaterThomas Kirmeier
Aug 22, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Frauke AssmusAleksandra Galetin

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Citations

Jun 20, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Carl PeterssonHugues Dolgos
Jun 26, 2020·Expert Opinion on Drug Discovery·Hanumanth Srikanth CheruvuMichael S Roberts
Jan 6, 2021·Pharmaceutics·Miriam AyusoSteven Van Cruchten

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