Application of the Wei-Lachin multivariate one-directional test to multiple event-time outcomes

Clinical Trials : Journal of the Society for Clinical Trials
John M Lachin, Ionut Bebu

Abstract

Cardiovascular outcome trials, among others, aim to assess the beneficial effects of a treatment on multiple event-time outcomes, such as the time to a myocardial infarction and the time to a stroke. The traditional approach is to conduct a simple analysis of a composite outcome defined as the time to the first component event using a logrank test or the Cox Proportional Hazards regression model. This ignores information from other component events after the first. The composite outcome analysis also treats all initial outcome events as equally important, for example, non-fatal myocardial infarction is as important as cardiovascular death. Herein, we describe the application of the Wei-Lachin multivariate one-sided (or one-directional) test to the analysis of multiple event-time outcomes. The test is based on the unweighted mean of the treatment group coefficients from individual Cox proportional hazards models fit to the outcomes, where the covariance of the set of coefficients is obtained from a partitioning of the information sandwich estimate. A weighted test is also described, weighing the outcomes by a scoring of their clinical importance. These and other methods are compared with application to the Prevention of Events w...Continue Reading

Citations

Jul 13, 2017·Journal of Comparative Effectiveness Research·Sarah Wamala Andersson, Mattias Kyhlstedt
Jul 10, 2018·Journal of Biopharmaceutical Statistics·Robin RistlMartin Posch
Jul 13, 2019·PloS One·John M LachinNaji Younes
Sep 9, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·W PoonJ C Vester
Jun 13, 2019·BMC Medical Research Methodology·Ann-Kathrin Ozga, Geraldine Rauch
Apr 17, 2021·Statistics in Medicine·Edgar BrunnerTobias Mütze
Nov 25, 2021·Statistics in Medicine·Song YangEric Leifer
Dec 7, 2021·Statistical Methods in Medical Research·Marta Bofill Roig, Guadalupe Gómez Melis

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Software Mentioned

SAS
R
R package multcomp
R survival package
SAS PHREG

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