PMID: 15209406Jun 24, 2004Paper

Application of toxicogenomics to toxicology: basic concepts in the analysis of microarray data

Toxicologic Pathology
Richard D IrwinRichard S Paules

Abstract

Toxicology and the practice of pathology are rapidly evolving in the postgenomic era. Observable treatment related changes have been the hallmark of toxicology studies. Toxicogenomics is a powerful new tool that may show gene and protein changes earlier and at treatment levels below the limits of detection of traditional measures of toxicity. It may also aid in the understanding of toxic mechanisms. It is important to remember that it is only a tool and will provide meaningful results only when properly applied. As is often the case with new experimental tools, the initial utilization is driven more by the technology than application to problem solving. Toxicogenomics is interdisciplinary in nature including at a minimum, pathology, toxicology, and genomics. Most studies will require the input from the disciplines of toxicology, pathology, molecular biology, bioinformatics, biochemistry, and others depending on the types of questions being asked.

References

Jul 1, 1986·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·P G Wells, E C To
Jul 1, 1995·Toxicology and Applied Pharmacology·M E BlazkaM I Luster
Feb 1, 1997·Kidney International·K Jungermann, T Kietzmann
Feb 14, 1998·The Biochemical Journal·T Oinonen, K O Lindros
Dec 1, 1996·Nature Biotechnology·D J LockhartE L Brown
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Jan 23, 1999·Nature Genetics·D J DugganJ M Trent
Jan 23, 1999·Nature Genetics·R J LipshutzD J Lockhart
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H F TeutschE Groezinger
Jul 27, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J R FryN W Thomas
Apr 25, 2000·Nucleic Acids Research·J SchuchhardtH Herzel
Apr 25, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·W D PennieI Kimber
Aug 30, 2000·Nature·C M PerouD Botstein
Dec 6, 2000·American Journal of Respiratory Cell and Molecular Biology·N Kaminski
Jan 3, 2001·Toxicology and Applied Pharmacology·L M CrosbyK T Morgan
May 31, 2001·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·M K KerrG A Churchill
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·C S BrownP K Sorger
Oct 5, 2001·Seminars in Liver Disease·R Bataller, D A Brenner
Dec 14, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·N KinnmanC Housset
Dec 26, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stefan U RueppFrançois Pognan
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mohammed BourdiLance R Pohl
Feb 7, 2002·Journal of Hepatology·David CassimanTania Roskams
Feb 28, 2002·Biochemical and Biophysical Research Communications·Eszter HazaiKatalin Monostory
Mar 14, 2002·Toxicologic Pathology·Gary A BoormanKevin T Morgan
Mar 26, 2002·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Edward R DoughertyJeffrey M Trent
Aug 22, 2002·Toxicologic Pathology·Hisham K HamadehRichard S Paules
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·James P BrodyStephen R Quake
Nov 28, 2002·Nature Genetics·Gary A Churchill
Nov 28, 2002·Nature Genetics·John Quackenbush
Dec 17, 2002·Chemical Research in Toxicology·Cynthia JuLance R Pohl
Mar 26, 2003·Liver International : Official Journal of the International Association for the Study of the Liver·Anna M WilliamsRobin D Hughes
Mar 28, 2003·Lancet·Jan M SchwabStefan Laufer
Apr 8, 2003·Toxicology·Susan D HesterDouglas C Wolf
May 2, 2003·Bioinformatics·K DobbinR Simon

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Citations

Jan 22, 2010·Archives of Pharmacal Research·Seung Jun Kim, Se Young Choung
Dec 13, 2006·Toxicologic Pathology·Julie F FoleyAlexandra N Heinloth
Jul 8, 2009·Critical Reviews in Food Science and Nutrition·Ulf HammerlingNils-Gunnar Ilbäck
Jun 23, 2010·Reproductive Biology and Endocrinology : RB&E·Gargi BagchiDavid J Waxman
Jan 25, 2012·Journal of Toxicologic Pathology·Takeki UeharaToshiyuki Maruyama
Nov 8, 2013·Environmental Science and Pollution Research International·Mi-Kyung SongJae-Chun Ryu
Jun 27, 2014·BioMed Research International·Prabhat SinghSrikanta Kumar Rath
Oct 30, 2008·Journal of Immunotoxicology·Kirsten A BakenHenk van Loveren
Jul 26, 2011·Toxicology and Applied Pharmacology·Takeki UeharaTetsuro Urushidani
May 27, 2015·Journal of Applied Toxicology : JAT·Zhouquan LiHeping Dai
Mar 5, 2013·Journal of Applied Toxicology : JAT·Pius JosephRajendran Sellamuthu
Jul 11, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Zhenlin JuRonald B Walter
May 17, 2006·Toxicology and Applied Pharmacology·Hiroyoshi ToyoshibaChristopher J Portier
Jul 5, 2015·International Journal of Hygiene and Environmental Health·Mi-Kyung Song, Jae-Chun Ryu
Jul 7, 2009·The Journal of Veterinary Medical Science·Hye-Jung YeomSeung Yong Hwang
Nov 13, 2013·Drug Discovery Today·Saifur R KhanArno G Siraki
Apr 5, 2005·Toxicologic Pathology·David E MalarkeyRobert R Maronpot
Feb 25, 2005·Human & Experimental Toxicology·Jon M Battershill
Dec 18, 2015·Dose-response : a Publication of International Hormesis Society·Jaya ChilakapatiKirk T Kitchin
Jan 5, 2007·The Journal of Toxicological Sciences·Katsumi MorishitaTetsuro Urushidani
Jul 11, 2008·Environmental Toxicology and Chemistry·Kimberly D MagriniShivanthi Anandan
Dec 11, 2007·The Journal of Biological Chemistry·Bekim SadikovicDavid I Rodenhiser
Sep 29, 2009·Molecular and Cellular Biochemistry·Christina UmbrightPius Joseph

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