Application of umbilical cord serum eyedrops for the treatment of dry eye syndrome

Cornea
Kyung-Chul YoonJin Choi

Abstract

To investigate the efficacy of umbilical cord serum eyedrops for the treatment of severe dry eye syndrome. Fifty-five eyes of 31 patients with severe dry eye syndrome were treated with umbilical cord serum eyedrops. Symptom scoring, tear film break-up time (BUT), Schirmer test, corneal sensitivity test, and corneal fluorescein staining were performed before and 1 and 2 months after treatment, and conjunctival impression cytology was performed before and 2 months after treatment. The concentrations of epidermal growth factor (EGF), vitamin A, and transforming growth factor-beta (TGF-beta) in umbilical cord serum and normal peripheral blood serum were measured. Two months after treatment, significant improvement was observed in symptom score (from 3.07 +/- 0.54 to 0.96 +/- 0. 58), BUT (from 3.96 +/- 1.56 to 5.45 +/- 2.54 seconds), and keratoepitheliopathy score (from 4.87 +/- 3.22 to 1.71 +/- 1.84) (P < 0.01). There was no statistically significant change in Schirmer and corneal sensitivity tests. In impression cytology, the grade of squamous metaplasia (from 2.35 +/- 0.72 to 1.44 +/- 0.69) and goblet cell density (from 80.91 +/- 31.53 to 154.68 +/- 43.06 cell/mm) improved significantly (P < 0.01). The mean concentrations of EGF,...Continue Reading

References

Jan 1, 1988·Cornea·J D Nelson
Jun 1, 1996·Current Eye Research·A GuptaS C Pflugfelder
Aug 6, 1999·The British Journal of Ophthalmology·K TsubotaS Shimmura
Sep 29, 1999·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·V M BorderieL Laroche
Nov 7, 2000·International Ophthalmology Clinics·K Tsubota, A Higuchi
Sep 25, 2001·The British Journal of Ophthalmology·A C PoonJ T Daniels
Nov 28, 2001·Cytopathology : Official Journal of the British Society for Clinical Cytology· AnshuA Ganar
Nov 1, 2002·Cornea·Jose Manuel Benítez del CastilloJulian García Sánchez
Nov 12, 2003·The British Journal of Ophthalmology·R B VajpayeeS A Melki
Jun 5, 2004·Ophthalmology·Yukihiro MatsumotoKazuo Tsubota

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Citations

Jul 9, 2008·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·G GeerlingD Hartwig
Aug 12, 2009·Clinical Ophthalmology·Koray Gumus, Dwight H Cavanagh
May 11, 2011·Medicinski pregled·Gordana Stanković BabićMilena Vujanović
Feb 26, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ali Riza Cenk CelebiG Ertugrul Mirza
May 3, 2014·International Journal of Pediatric Otorhinolaryngology·Chul Ho JangGeun Hyung Kim
Feb 19, 2013·Archivos de la Sociedad Española de Oftalmología·A V Sánchez Ferreiro, L Muñoz Bellido
Dec 15, 2015·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Ting WangWeiyun Shi
May 12, 2007·American Journal of Ophthalmology·Kyung-Chul YoonYeoung-Geol Park
Sep 22, 2012·Acta Ophthalmologica·Kyung-Chul YoonJin Choi
Jun 17, 2015·Survey of Ophthalmology·Ryan B Nugent, Graham A Lee
Oct 3, 2012·Current Eye Research·Han-Jin OhKyung-Chul Yoon
Nov 6, 2014·The British Journal of Ophthalmology·Namrata SharmaRasik B Vajpayee
Dec 4, 2014·International Journal of Pediatric Otorhinolaryngology·Yoon Seok JangGeun Hyung Kim
Jan 9, 2015·Chonnam Medical Journal·Kyung Chul Yoon
Feb 12, 2019·Cutaneous and Ocular Toxicology·Kyung Eun HanRoo Min Jun
Sep 20, 2019·Journal of Clinical Medicine·Federico BernabeiPiera Versura
Jun 2, 2018·Journal of Ophthalmology·Sang Beom HanJodhbir S Mehta
Feb 29, 2020·Ophthalmology and Therapy·Giuseppe GiannaccareVincenzo Scorcia
Sep 29, 2020·Clinical Ophthalmology·Mohammad Soleimani, Morteza Naderan

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