Application of volumetric MR spectroscopic imaging for localization of neocortical epilepsy.

Epilepsy Research
A A MaudsleyBrian C Bowen

Abstract

The aim of this study was to evaluate volumetric proton magnetic resonance spectroscopic imaging (MRSI) for localization of epileptogenic foci in neocortical epilepsy. Twenty-five subjects reporting seizures considered to be of neocortical origin were recruited to take part in a 3-T MR study that included high-resolution structural MRI and a whole-brain MRSI acquisition. Using a fully automated MRSI processing protocol, maps for signal intensity normalized N-acetylaspartate (NAA), creatine, and choline were created, together with the relative volume fraction of grey-matter, white-matter, and CSF within each MRSI voxel. Analyses were performed using visual observation of the metabolite and metabolite ratio maps; voxel-based calculation of differences in these metabolite maps relative to normal controls; comparison of average grey-matter and white-matter metabolite values over each lobar volume; and examination of relative left-right asymmetry factors by brain region. Data from 14 subjects were suitable for inclusion in the analysis. Eight subjects had MRI-visible pathologies that were associated with decreases in NAA/creatine, which extended beyond the volume indicated by the MRI. Five subjects demonstrated no significant metabo...Continue Reading

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Citations

Apr 4, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Eva-Margarete SpurLeo L Cheng
Feb 27, 2014·Radiology·Gülin OzUNKNOWN MRS Consensus Group
Oct 30, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mohammad SabatiAndrew A Maudsley
Nov 29, 2014·Journal of Magnetic Resonance Imaging : JMRI·Angèle LecocqJean-Philippe Ranjeva
Feb 22, 2012·European Journal of Medical Genetics·Grace J NohJohn M Graham
Oct 4, 2016·NeuroImage·Andrew A MaudsleySulaiman Sheriff
Oct 3, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shang-Yueh TsaiFa-Hsuan Lin
May 1, 2020·NMR in Biomedicine·Andrew A MaudsleyBrian J Soher
Jul 31, 2013·Epilepsia·Jullie W PanDennis D Spencer
Sep 29, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Abas Abdoli, Andrew A Maudsley
Mar 10, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Xiao-Qi DingKai G Kahl
May 5, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Adam M Goodman, Jerzy P Szaflarski

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