Application of Y-chromosomal microdeletions in a homicide case.

Forensic Science International : Synergy
Xingyi YangWeian Du

Abstract

A case study involving an intentional homicide case in November 2018, in which the autosomal genotypes of the suspect were unavailable and only part of deletions of Y-STR loci were identified by Y-chromosomal typing. The suspect, male, was charged with beating the decedent, female, over the head with an iron water pipe to death. The use of standard autosomal DNA profiling to identify the suspect was unattainable due to the extensive volume blood of the decedent on the murder weapon which was inevitably cleaned by running water at the crime scene. As a result, autosomal genotypes of the suspect were unavailable and only partial samples of deletions of Y-STR loci were identified by Y-chromosomal typing. Y-STR analysis (Yfiler™ plus and AGCU Y36) was used on the collected DNA extracts and compared to reference samples of the suspect, as well as his father and brother in an attempt to positively identify the suspect as the perpetrator of the murder. Subsequent Y-STR genotyping for the suspect, his father and brother indicated that Y-STR genotype of the suspect was consistent with that discovered on the physical evidence and the deleted Y-STR loci were identical for both. No deletions of Y-STR genotype were observed in the suspect's...Continue Reading

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