Application of Zebrafish Models in Inflammatory Bowel Disease

Frontiers in Immunology
Li HanyangRan Zhihua

Abstract

Inflammatory bowel disease (IBD) is a chronic, recurrent, and remitting inflammatory disease with unclear etiology. As a clinically frequent disease, it can affect individuals throughout their lives, with multiple complications. Unfortunately, traditional murine models are not efficient for the further study of IBD. Thus, effective and convenient animal models are needed. Zebrafish have been used as model organisms to investigate IBD because of their suggested highly genetic similarity to humans and their superiority as laboratory models. The zebrafish model has been used to study the composition of intestinal microbiota, novel genes, and therapeutic approaches. The pathogenesis of IBD is still unclear and many risk factors remain unidentified. In this review, we compare traditional murine models and zebrafish models in terms of advantages, pathogenesis, and drug discovery screening for IBD. We also review the progress and deficiencies of the zebrafish model for scientific applications.

References

May 1, 1992·Gastroenterology·Y YamadaM B Grisham
Aug 9, 1991·Science·K W KinzlerD McKechnie
Oct 1, 1995·Gastroenterology·C O ElsonR H Riddell
Dec 1, 1994·Gastroenterology·J P SundbergE H Birkenmeier
Jan 14, 2000·Nature Biotechnology·J G Burkhart
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·John F RawlsJeffrey I Gordon
Jan 18, 2005·Mechanisms of Development·Kenneth N WallaceMichael Pack
Aug 30, 2005·Developmental Biology·Annie N Y NgJoan K Heath
Oct 6, 2005·Journal of Biochemistry and Molecular Biology·Dian-Chang ZhangShi-Gui Jiang
Dec 27, 2005·Inflammatory Bowel Diseases·Stephen B Hanauer
Jan 28, 2006·EMBO Reports·Anna-Pavlina G HaramisHans C Clevers
Feb 8, 2006·Annual Review of Physiology·Christina M Van Itallie, James M Anderson
Mar 16, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephan BrandJulia Dambacher
Mar 23, 2006·Infection and Immunity·Astrid M van der SarAnnemarie H Meijer
Jun 20, 2006·Developmental Biology·Jennifer M BatesKaren Guillemin
Jul 11, 2006·Zeitschrift für Gastroenterologie·M Zöller
Jan 5, 2007·Genome Biology·Albert ZlotnikHisayuki Nomiyama
Jan 16, 2007·Research in Microbiology·Sarah E Cheesman, Karen Guillemin
Mar 9, 2007·Inflammatory Bowel Diseases·Kara J Gross, Charalabos Pothoulakis
Apr 19, 2007·Nature Reviews. Genetics·Graham J Lieschke, Peter D Currie
Jun 21, 2007·Molecular Cancer Research : MCR·Sebastian KuhnMargot Zöller
Sep 20, 2007·The Journal of Comparative Neurology·Paul M Forlano, Roger D Cone
Jul 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Efi KokkotouCharalabos Pothoulakis
Nov 26, 2008·General and Comparative Endocrinology·Navpreet Amole, Suraj Unniappan
Feb 18, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rudolf MennigenMatthias Bruewer
Aug 25, 2009·Gastroenterology·Sylvia BrugmanEdward E S Nieuwenhuis
Nov 6, 2009·The New England Journal of Medicine·Erik-Oliver GlockerChristoph Klein
Nov 28, 2009·Developmental and Comparative Immunology·Stefan H B OehlersPhilip S Crosier
Dec 22, 2009·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Ken-Ichiro Tanaka, Tohru Mizushima
Jun 10, 2010·The Journal of Comparative Neurology·Lars BräutigamGiselbert Hauptmann
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sarah E CheesmanKaren Guillemin
Nov 26, 2010·Developmental and Comparative Immunology·Stefan H OehlersPhilip S Crosier
Dec 25, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Stefan H OehlersPhilip S Crosier
Mar 2, 2011·European Journal of Immunology·Jolanda M van DierenEdward E S Nieuwenhuis
Mar 8, 2011·Inflammatory Bowel Diseases·Gheorghe HundorfeanJonas Mudter

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Citations

Jul 13, 2021·Frontiers in Immunology·Tuula Peñate MedinaJan-Bernd Hövener

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Methods Mentioned

BETA
transgenic
electron microscopy
glycosylation
fluorescence-activated cell sorting
chemical treatments

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