[Application procedures and dosage recommendations for postoperative analgesia.].

Der Schmerz
W Dick, R Janik

Abstract

Systemic application of analgesics is still the most frequently used method of postoperative relief of pain. However, neither intermittent intramuscular nor intermittent intravenous application can provide the patient with a continuous level of analgesia. Lipid-soluble analgesics or those with polar binding that are rapidly metabolized demonstrate an rapid effectiveness. If the analgesia must be administered over a long period, it is due to a low level of lipid solubility, high receptor affinity and low elimination rates. Oral as well as sublingual buccal and rectal applications are characterized by uncertain absorption conditions. There are few investigations on the subcutaneous application of analgesics. After intramuscular administration analgesic levels are achieved within 15 to 60 min, but various conditions may alter the absorption criteria. Intradeltoidal application is preferable to intragluteal injection. Analgesics may be administered intravenously as a bolus, as continuous infusion, or as patient-controlled analgesia. The bolus injection is characterized by a short period of action and the necessity to administer several bolus injections by repeated administration. The continuous infusion of analgesics should begin w...Continue Reading

References

Oct 1, 1979·Acta Anaesthesiologica Scandinavica·A TamsenM H Holmdahl
Nov 1, 1978·British Journal of Anaesthesia·J R RiggC H Goldsmith
Dec 1, 1977·Clinical Pharmacology and Therapeutics·M EhrneboU Lönroth
May 1, 1976·British Journal of Anaesthesia·J G WhitwamA Petrie
Feb 1, 1988·Journal of Clinical Periodontology·I AukhilD M Simpson
Jan 1, 1985·The Annals of Thoracic Surgery·S E FremesP R McLaughlin
Mar 1, 1985·British Journal of Anaesthesia·W S Nimmo, J G Todd
Nov 1, 1966·Clinical Pharmacology and Therapeutics·W T BeaverA Rogers
Jan 21, 1984·British Medical Journal·H McQuay, A Moore
Feb 1, 1983·Critical Care Medicine·B J KripkeH B Hechtman
Apr 29, 1983·Deutsche medizinische Wochenschrift·K A Lehmann
Jan 1, 1983·Journal of Clinical Pharmacology·P Y GrabinskiR W Houde
Feb 19, 1982·JAMA : the Journal of the American Medical Association·W A Check
Mar 1, 1982·Canadian Anaesthetists' Society Journal·J S SpriggeD R Bevan
Oct 1, 1982·Acta Anaesthesiologica Scandinavica·L RybroM Wernberg
Dec 1, 1980·Anesthesiology·C C Hug
Nov 13, 2001·Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·A Thiel, M Ritzka

❮ Previous
Next ❯

Citations

Jan 1, 1991·Critical Reviews in Microbiology·L PolonelliG Morace

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.