Applications and opportunities of experimental design for the dispersive liquid-liquid microextraction method - A review

Talanta
Leila MousaviMohammad Reza Khoshayand

Abstract

Nowadays, the trend to simplify and miniaturize sample preparation methods has resulted in the development of effective and low-cost microextraction techniques that utilize a very small volume of the extracting phase. Among them, the liquid-liquid microextraction (LLME) method is a simple and effective sample pre-treatment technique applicable to numerous analytical methods. A related miniaturized and environmentally friendly extraction technique, dispersive liquid-liquid microextraction (DLLME), has been developed within the last decade and shows a very high enrichment factor and very low solvent consumption compared to other liquid- or even solid-phase extraction methods. The inclusion of several effective parameters in DLLME and its variants has increased the need for optimization to obtain the best possible extraction results. In fact, experimental design and optimization of performance conditions are the most important applications of chemometrics in analytical chemistry. Thus, design of experiments (DoE) helps us to determine the best model of the relationship between variables, as well as the optimal experimental conditions. Here, a comprehensive review of recent advancements in the use of DoE methodologies including ful...Continue Reading

Citations

Nov 18, 2019·Biomedical Chromatography : BMC·Azamat TemerdashevElina Gashimova
Oct 1, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Alireza Tabibi, Mohammad T Jafari
Mar 11, 2020·International Journal of Environmental Research and Public Health·Ivan NotardonatoPasquale Avino
Aug 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ying XueJing Xie
Jan 15, 2020·Critical Reviews in Biotechnology·Sharifah Fathiyah Sy MohamadWan Mohd Azizi Wan Sulaiman
Aug 14, 2020·Environmental Science and Pollution Research International·Rhiane Ramos Rocha CarvalhoJairo Lisboa Rodrigues
Nov 21, 2020·Electrophoresis·Li-Qing Peng, Jun Cao
Dec 1, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Arun ButreddyMichael A Repka
Feb 6, 2021·Electrophoresis·Icaro Salgado PerovaniAnderson Rodrigo Moraes de Oliveira
Mar 5, 2021·Biomedical Chromatography : BMC·Seyed Mosayeb DaryanavardMohamed Abdel-Rehim
May 17, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marcela Tavares LuizDelia Rita Tapia-Blácido
Oct 19, 2019·Analytical Chemistry·Frederik A Hansen, Stig Pedersen-Bjergaard
Jan 29, 2020·Analytical Chemistry·Shane S Wells, Robert T Kennedy
Sep 27, 2021·Comprehensive Reviews in Food Science and Food Safety·Fernanda C O L MartinsWanessa R Melchert
Oct 16, 2021·Analytical and Bioanalytical Chemistry·Iran Ocaña-RiosKingsley K Donkor

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