Applications of Converged Various Forces for Detection of Biomolecules and Novelty of Dielectrophoretic Force in the Applications.

Sensors
Seungjun LeeJinsik Kim

Abstract

Since separation of target biomolecules is a crucial step for highly sensitive and selective detection of biomolecules, hence, various technologies have been applied to separate biomolecules, such as deoxyribonucleic acid (DNA), protein, exosome, virus, etc. Among the various technologies, dielectrophoresis (DEP) has the significant advantage that the force can provide two different types of forces, attractive and repulsive DEP force, through simple adjustment in frequency or structure of microfluidic chips. Therefore, in this review, we focused on separation technologies based on DEP force and classified various separation technologies. First, the importance of biomolecules, general separation methods and various forces including DEP, electrophoresis (EP), electrothermal flow (ETF), electroosmosis (EO), magnetophoresis, acoustophoresis (ACP), hydrodynamic, etc., was described. Then, separating technologies applying only a single DEP force and dual force, moreover, applying other forces simultaneously with DEP force were categorized. In addition, advanced technologies applying more than two different kinds of forces, namely complex force, were introduced. Overall, we critically reviewed the state-of-the-art of converged various...Continue Reading

References

Dec 1, 1976·Biophysical Chemistry·F Hutchinson, F Krasin
Nov 23, 2000·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·N G GreenA Castellanos
Apr 4, 2002·Postgraduate Medical Journal·J W WilsonC A Nickerson
Aug 3, 2002·Nature Reviews. Immunology·Clotilde ThérySebastian Amigorena
Apr 21, 2009·Methods in Molecular Biology·Edward P TrieuIra N Targoff
Aug 26, 2009·Lab on a Chip·Jason P BeechJonas O Tegenfeldt
Feb 4, 2010·Lab on a Chip·Chihchen ChenDaniel Irimia
Feb 25, 2010·Chemical Society Reviews·Andreas Lenshof, Thomas Laurell
Apr 28, 2010·Electrophoresis·Ewa KłodzińskaBogusław Buszewski
Dec 25, 2010·JALA : Journal of the Association for Laboratory Automation·Mandy L Y SinPak Kin Wong
Jun 28, 2011·Journal of Microbiological Methods·Jeff A BradyForrest L Mitchell
Nov 30, 2011·Analytica Chimica Acta·Zaifang ZhuShaorong Liu
May 11, 2012·Proteome Science·Xiangpeng RenYongchang Cao
Feb 8, 2013·Optics Express·Rebecca K MontangeThomas T Perkins
Feb 14, 2013·Scientific Reports·Han Wei HouChwee Teck Lim
Oct 8, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Ceren TürkcanAdil Denizli
Dec 3, 2013·Analytical Biochemistry·Ji Hyun MinYoung Keun Kim
Jul 9, 2014·Lab on a Chip·Joel S PaustianTodd M Squires
Sep 13, 2014·Lab on a Chip·J McGrathH Bridle
Nov 15, 2014·Journal of Extracellular Vesicles·Dennis K JeppesenMarie S Ostenfeld
Dec 3, 2014·Journal of Chromatography. a·Mitja L HeinemannJody Vykoukal
Feb 13, 2015·ACS Nano·Kyungheon LeeHakho Lee
May 6, 2015·Lab on a Chip·A LigaM Kersaudy-Kerhoas
Nov 8, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Takuma YamashitaYoshinobu Takakura
Dec 31, 2016·Journal of Separation Science·Anas AlazzamFalah Alhammadi
Feb 6, 2017·Scientific Reports·Alban J SmithChristopher D Wood
Mar 4, 2017·Theranostics·Pin LiZhiqiang Gao
Mar 4, 2017·Endocrinology and Metabolism·Chang Hun Lee
Jul 4, 2017·ACS Nano·Stuart D IbsenMichael J Heller

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Citations

Sep 29, 2021·Biomedical Microdevices·Mehdi Rahmati, Xiaolin Chen

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Methods Mentioned

BETA
chip
size exclusion chromatography
enzyme-linked immunosorbent assay
optical tweezer
chips

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