Applications of Gelatin Methacryloyl (GelMA) Hydrogels in Microfluidic Technique-Assisted Tissue Engineering.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Taotao LiuHuazhe Yang

Abstract

In recent years, the microfluidic technique has been widely used in the field of tissue engineering. Possessing the advantages of large-scale integration and flexible manipulation, microfluidic devices may serve as the production line of building blocks and the microenvironment simulator in tissue engineering. Additionally, in microfluidic technique-assisted tissue engineering, various biomaterials are desired to fabricate the tissue mimicking or repairing structures (i.e., particles, fibers, and scaffolds). Among the materials, gelatin methacrylate (GelMA)-based hydrogels have shown great potential due to their biocompatibility and mechanical tenability. In this work, applications of GelMA hydrogels in microfluidic technique-assisted tissue engineering are reviewed mainly from two viewpoints: Serving as raw materials for microfluidic fabrication of building blocks in tissue engineering and the simulation units in microfluidic chip-based microenvironment-mimicking devices. In addition, challenges and outlooks of the exploration of GelMA hydrogels in tissue engineering applications are proposed.

References

May 14, 1993·Science·R Langer, J P Vacanti
Nov 17, 2001·Biomacromolecules·A I Van Den BulckeH Berghmans
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ali KhademhosseiniJoseph P Vacanti
Sep 15, 2006·Journal of the Royal Society, Interface·Yoshito Ikada
Aug 21, 2007·Biomaterials·Ali Khademhosseini, Robert Langer
Oct 22, 2008·Biomaterials·Natalja E FedorovichWouter J A Dhert
Feb 4, 2010·Lab on a Chip·Jong Hwan SungMichael L Shuler
Feb 25, 2010·Chemical Society Reviews·Daniel MarkRoland Zengerle
Apr 27, 2010·Biomaterials·Jason W NicholAli Khademhosseini
Jul 19, 2008·Annual Review of Analytical Chemistry·Ivar Meyvantsson, David J Beebe
Jul 20, 2011·Journal of the American Chemical Society·Halil TekinAli Khademhosseini
Jan 25, 2013·International Journal of Nanomedicine·Tingli LuTao Chen
Apr 30, 2013·Polymers·Seila SelimovićAli Khademhosseini
Apr 4, 2014·Biofabrication·Luiz E BertassoniAli Khademhosseini
May 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Nurettin Sahiner, Selin Sagbas
Dec 3, 2014·Drug Discovery Today·Hiroaki Onoe, Shoji Takeuchi
Apr 17, 2015·Advanced Healthcare Materials·Xin ZhaoAli Khademhosseini
Nov 27, 2015·Advanced Materials·Cristina ColosiAli Khademhosseini
Jan 3, 2016·Biotechnology Advances·Christian MandryckyDeok-Ho Kim
Feb 13, 2016·Trends in Biotechnology·Barbara J KlotzFerry P W Melchels
Feb 16, 2016·Nature Biotechnology·Hyun-Wook KangAnthony Atala
Apr 22, 2016·Lab on a Chip·Aereas AungShyni Varghese
Jun 21, 2016·Biofabrication·Stephanie KnowltonSavas Tasoglu
Oct 6, 2016·Biomicrofluidics·Steven A RobertsMichael A Daniele
Oct 19, 2016·Lab on a Chip·Yu Shrike ZhangRahmi Oklu
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Danfeng CaoZuosen Shi
Nov 9, 2016·Acta Biomaterialia·Xin ZhaoAli Khademhosseini
Feb 9, 2017·Electrophoresis·Jong Min LeeBong Geun Chung
May 4, 2017·Advanced Healthcare Materials·Wanjun LiuYu Shrike Zhang
Jun 22, 2017·Methods in Molecular Biology·Cristina ColosiMariella Dentini
Aug 23, 2017·Journal of Visualized Experiments : JoVE·Yu Shrike ZhangAnne Metje van Genderen
Nov 18, 2017·Macromolecular Bioscience·Marilyn C McNamaraNicole N Hashemi

❮ Previous
Next ❯

Methods Mentioned

BETA
chips
bioprinting
bioprinter
chip
one-chip

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.