PMID: 7082020May 1, 1982Paper

Applications of glucocorticosteroids. The effects of twice-daily vs once-every-other-day applications on mouse epidermal cell DNA synthesis

Archives of Dermatology
A du VivierM Hehir


To determine a schedule for continuous suppression of epidermal cell DNA synthesis, 0.05% fluocinonide ointment was applied either twice daily or once on alternate days to hairless mouse skin for 174 hours. Suppression occurred similarly for both regimens for 78 hours followed by an increase in DNA synthesis despite continued application of fluocinonide. The systemic effect was less marked with the alternate-day schedule. The effect of a single application of the fluocinonide ointment was also studied over 174 hours. Substantial inhibition of DNA synthesis occurred but for a shorter period followed by an increase and then return to normal values. Experiments were performed where second applications were made at various time intervals after the first. These did not appear to affect events until 192 hours had elapsed, when a second application caused profound inhibition of DNA synthesis once more.


Jun 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Florian SpörlAchim Kramer
Jan 22, 2013·Cellular and Molecular Life Sciences : CMLS·Xiao-Yong ManMin Zheng
Mar 2, 2005·The Journal of Investigative Dermatology·Eung-Ho ChoiK R Feingold
Feb 25, 2009·Experimental Dermatology·Marianne DemerjianK R Feingold
May 13, 2006·Experimental Dermatology·Stefanie SchoepeKhusru Asadullah
Jan 1, 1985·Clinical and Experimental Dermatology·M ClementA du Vivier
Feb 5, 1990·The Medical Journal of Australia·H Rotstein, C Baker

Related Concepts

Administration, Topical
Anti-Inflammatory Agents
DNA, Double-Stranded
Drug Administration Schedule
Glucocorticoid Effect
Mice, hr

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