Applications of Immunohistochemistry to Endocrine Pathology

Advances in Anatomic Pathology
Sara E Higgins, Justine A Barletta

Abstract

The role of immunohistochemistry (IHC) in endocrine pathology is similar to that in other organ systems in that it can aid in the subclassification of tumors within an organ, confirm site of primary in metastatic disease, provide prognostic information, identify underlying genetic alterations, and predict response to treatment. Although most endocrine tumors do not require IHC to render a diagnosis, there are certain scenarios in which IHC can be extremely helpful. For example, in thyroid, IHC can be used to support tumor dedifferentiation, in the adrenal it can aid in the diagnosis of low-grade adrenocortical carcinomas, and in paragangliomas it can help identify tumors arising as part of an inherited tumor syndrome. This review will focus on the applications of IHC in tumors of the thyroid, parathyroids, adrenals, and paraganglia in adults.

References

Aug 1, 1987·The American Journal of Surgical Pathology·J A CarneyJ R Goellner
Sep 1, 1989·Japanese Journal of Medicine·T MaedaK Shimamoto
Nov 1, 1984·The Journal of Clinical Endocrinology and Metabolism·M F SaadN A Samaan
Jan 1, 1983·Human Pathology·J Albores-SaavedraA R Morales
May 1, 1997·The American Journal of Surgical Pathology·M P VargasM J Merino
Dec 14, 1999·Annals of Diagnostic Pathology·H R HarachM Longy
Mar 18, 2000·Advances in Anatomic Pathology·N G Ordóñez
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S N AgoffA L Folpe
Apr 11, 2000·The American Journal of Surgical Pathology·M Hirokawa, J A Carney
Sep 12, 2000·Applied Immunohistochemistry & Molecular Morphology : AIMM·P A BejaranoP W Biddinger
Feb 24, 2001·Endocrine Research·J ArolaP Heikkilä
Apr 11, 2001·American Journal of Clinical Pathology·J Cameselle-TeijeiroM Sobrinho-Simoes
Apr 13, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·C C CheungS L Asa
May 10, 2002·The New England Journal of Medicine·Hartmut P H NeumannUNKNOWN Freiburg-Warsaw-Columbus Pheochromocytoma Study Group
Feb 28, 2003·Human Pathology·Alexander StojadinovicRonald A Ghossein
Jun 17, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paul J ZhangVirginia A LiVolsi
Oct 31, 2003·The New England Journal of Medicine·Trisha M ShattuckAndrew Arnold
Aug 26, 2004·JAMA : the Journal of the American Medical Association·Hartmut P H NeumannUNKNOWN European-American Paraganglioma Study Group
Sep 11, 2004·Molecular and Cellular Endocrinology·Daniel Christophe
Oct 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Min-Han TanBin Tean Teh
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Filomena CetaniClaudio Marcocci
Jun 16, 2005·The Journal of Clinical Endocrinology and Metabolism·Linda J KrebsAndrew Arnold
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laurence AmarAnne-Paule Gimenez-Roqueplo
Dec 1, 2005·The Journal of Clinical Endocrinology and Metabolism·Diana E BennBruce G Robinson
Dec 6, 2005·Nature Reviews. Cancer·Eyal Gottlieb, Ian P M Tomlinson
May 26, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·Eugenio LeonardoMauro Papotti
Dec 7, 2007·The American Journal of Surgical Pathology·Koushan SiamiMichael T Deavers
Dec 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Daisuke NonakaRonald Ghossein

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Citations

Aug 29, 2019·AJR. American Journal of Roentgenology·Jiabing GuYong Yin
Jul 7, 2020·Seminars in Diagnostic Pathology·Jing Yang, Justine A Barletta
Apr 9, 2021·The Journal of International Medical Research·Sixu XinSanbao Chai

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