Applications of molecular genetics to gastrointestinal and liver diseases. I. Technical approaches

Journal of Gastroenterology and Hepatology
K M Summers

Abstract

Recent developments in recombinant DNA techniques have allowed an understanding of the molecular genetics of many diseases, some affecting the gastrointestinal tract and liver. DNA probes which detect sequences within or near disease genes can be selected by direct approaches, if the gene product or primary gene function is known, or by indirect methods when the chromosomal location is known. Such probes have resulted in extensive family studies which can now define risks to family members of developing a genetic disease. The development of the polymerase chain reaction will also be of considerable use in clinical genetics and in the diagnosis of some infectious diseases. The techniques are summarized and examples of their use are given. A glossary of terms is also provided.

References

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Citations

May 1, 1989·Journal of Gastroenterology and Hepatology·K M Summers
Nov 1, 1990·Journal of Gastroenterology and Hepatology·K M Summers
Jul 28, 2005·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Harry FinkenflügelRobbert Huijsman

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