Applications of molecular MRI and optical imaging in cancer.

Future Medicinal Chemistry
Marie-France PenetZaver M Bhujwalla

Abstract

Some of the most exciting advances in molecular-functional imaging of cancer are occurring at the interface between chemistry and imaging. Several of these advances have occurred through the development of novel imaging probes that report on molecular pathways, the tumor micro-environment and the response of tumors to treatment; as well as through novel image-guided platforms such as nanoparticles and nanovesicles that deliver therapeutic agents against specific targets and pathways. Cancer cells have a remarkable ability to evade destruction despite the armamentarium of drugs currently available. While these drugs can destroy cancer cells, normal tissue toxicity is a major limiting factor, a problem further compounded by poor drug delivery. One major challenge for chemistry continues to be to eliminate cancer cells without damaging normal tissues. Here we have selected examples of MRI and optical imaging, to demonstrate how integrating imaging with novel probes can facilitate the successful treatment of this multifaceted disease.

References

Nov 7, 1999·Topics in Magnetic Resonance Imaging : TMRI·G J Parker, P S Tofts
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Feb 17, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·J E KoblinskiB F Sloane
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·J G FujimotoM E Brezinski
Sep 5, 2002·Nature Reviews. Cancer·Sanjiv Sam Gambhir
Jan 25, 2003·Methods : a Companion to Methods in Enzymology·William MohlerPaul J Campagnola
Feb 25, 2003·European Radiology·Christoph BremerRalph Weissleder
Feb 25, 2003·European Radiology·Heike E Daldrup-Link, Robert C Brasch
Jun 20, 2003·The New England Journal of Medicine·Mukesh G HarisinghaniRalph Weissleder
Aug 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jan H Ardenkjaer-LarsenKlaes Golman
Nov 25, 2003·Journal of Cellular Biochemistry·J Oliver McIntyre, Lynn M Matrisian
Feb 22, 2005·Current Opinion in Biotechnology·Andreas H Hielscher
Apr 12, 2005·The Journal of Thoracic and Cardiovascular Surgery·Cherie P ParungoJohn V Frangioni
Jul 16, 2005·American Journal of Obstetrics and Gynecology·Andrés F ZuluagaRebecca Richards-Kortum
Jul 19, 2005·Cancer Research·Xavier MontetRalph Weissleder
Sep 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jan GrimmRalph Weissleder
Nov 17, 2005·Cancer Research·Liora ShiftanMichal Neeman
Nov 19, 2005·Journal of Biomedical Optics·Petra Wilder-SmithBruce Tromberg
Nov 22, 2005·Nature Methods·Nathan C ShanerRoger Y Tsien
Feb 21, 2006·Cancer Research·Max S WichaGabriela Dontu
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Réginald AnsiauxBernard Gallez
Mar 2, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yoshinori KatoDmitri Artemov
May 27, 2006·Chemical Society Reviews·Mark WoodsA Dean Sherry
Aug 8, 2006·Nature Medicine·Patricia S Steeg
Sep 21, 2006·NMR in Biomedicine·Susan M Galbraith
Oct 13, 2006·Neoplasia : an International Journal for Oncology Research·Paul T WinnardVenu Raman
Jan 30, 2007·Nature Biotechnology·Assaf A GiladPeter C M van Zijl
Feb 27, 2007·Nature Medicine·Zdravka MedarovaAnna Moore
Mar 14, 2007·Cancer·Sevin BaserMadeleine Duvic
Apr 13, 2007·Nature·Roseanne J Sension
Jun 5, 2007·Trends in Molecular Medicine·Kristine GlundeZaver M Bhujwalla

❮ Previous
Next ❯

Citations

Jun 2, 2011·Chemical Communications : Chem Comm·Huihui YanCong Li
Feb 20, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tomáš EtrychKarsten Mäder
Jun 13, 2013·European Journal of Radiology·Marie-France PenetZaver M Bhujwalla
Feb 14, 2013·Journal of Cellular and Molecular Medicine·Santiago RouraAntoni Bayes-Genis
Sep 7, 2016·Contrast Media & Molecular Imaging·Sashiprabha M VithanarachchiMatthew J Allen
Jun 28, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Xihui GaoCong Li
Sep 12, 2018·Molecular Imaging·Mariya ShapovalovaAaron M LeBeau
Aug 20, 2014·Chemical Communications : Chem Comm·Victoria S R HarrisonThomas J Meade
Jul 17, 2012·Nanoscale·Mengistie L DebasuJoão Rocha
Jun 2, 2020·Frontiers in Medicine·Apekshya ChhetriJoseph V Rispoli
Oct 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lara G FreidusYahya E Choonara
Mar 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lixiu ChenZhengbao Zha
Jan 18, 2020·Bioconjugate Chemistry·Madiha SaeedHaijun Yu
Oct 11, 2021·International Journal of Pharmaceutics·Dnyaneshwar KalyaneRakesh Kumar Tekade

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
imaging techniques
irradiating
xenografts
transfection
biopsy
light scattering

Software Mentioned

FMT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.