Applications of NMR to membrane proteins

Archives of Biochemistry and Biophysics
Stanley J Opella, Francesca M Marassi

Abstract

Membrane proteins present a challenge for structural biology. In this article, we review some of the recent developments that advance the application of NMR to membrane proteins, with emphasis on structural studies in detergent-free, lipid bilayer samples that resemble the native environment. NMR spectroscopy is not only ideally suited for structure determination of membrane proteins in hydrated lipid bilayer membranes, but also highly complementary to the other principal techniques based on X-ray and electron diffraction. Recent advances in NMR instrumentation, spectroscopic methods, computational methods, and sample preparations are driving exciting new efforts in membrane protein structural biology.

Citations

Nov 10, 2018·Nature Reviews. Drug Discovery·Ichio ShimadaKurt Wüthrich
Dec 20, 2017·Biophysics Reviews·Kazuhiro Mio, Chikara Sato
Nov 2, 2018·International Journal of Molecular Sciences·Ashutosh SrivastavaFlorence Tama
Aug 16, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dae-Won SimJi-Hun Kim
Sep 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fred Naider, Jeffrey M Becker
Jan 6, 2019·International Journal of Molecular Sciences·CongBao Kang
Mar 17, 2019·International Journal of Molecular Sciences·Philipp Selenko
Nov 22, 2019·Frontiers in Molecular Biosciences·Laura Orellana
Jul 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qingxin Li, CongBao Kang
Jan 16, 2018·The Analyst·G LippensJ C Portais
Dec 31, 2020·International Journal of Molecular Sciences·Johannes Thoma, Björn M Burmann
Mar 30, 2021·Journal of Biomolecular NMR·Anna Sinelnikova, David van der Spoel
Apr 24, 2021·Journal of Molecular Biology·Andrei MironenkoWojciech Kopec
Dec 20, 2018·Journal of the American Chemical Society·Annalisa PastorePiero Andrea Temussi
May 7, 2020·Biochimica Et Biophysica Acta. Biomembranes·Sang Ho ParkStanley J Opella
May 18, 2020·Biochimica Et Biophysica Acta. Biomembranes·Gaddafi I Danmaliki, Peter M Hwang
May 18, 2020·Biochimica Et Biophysica Acta. Biomembranes·Luke S EvansPhilip T F Williamson
May 5, 2021·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Trần Thanh Tâm Phạm, Jan K Rainey

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