Applications of population approaches in toxicology

Toxicology Letters
F Y Bois

Abstract

Many experimental or observational studies in toxicology are best analysed in a population framework. Recent examples include investigations of the extent and origin of intra-individual variability in toxicity studies, incorporation of genotypic information to address intra-individual variability, optimal design of experiments, and extension of toxicokinetic modelling to the analysis of biomarker studies. Bayesian statistics provide powerful numerical methods for fitting population models, particularly when complex mechanistic models are involved. Challenges and limitations to the use of population models, in terms of basic structure, computational burden, ease of implementation and data accessibility, are identified and discussed.

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Citations

Mar 10, 2010·Nature Reviews. Genetics·Duncan Thomas
Jan 16, 2007·Journal of Biopharmaceutical Statistics·Fredrik JonssonScott Marshall
Nov 3, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Eva D McLanahanP M Schlosser
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Mar 9, 2002·Toxicology and Applied Pharmacology·Fredrik Jonsson, Gunnar Johanson
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Jun 15, 2004·Fertility and Sterility·Ho-Yuan ChangPing-Chi Hsu

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