Applications of proteomic methodologies to human pregnancy research: a growing gestation approaching delivery?

Proteomics
Renu ShankarEric Keith Moses

Abstract

Maternal and perinatal morbidity and mortality rates are significantly higher in pregnancies complicated by preterm labor, pre-eclampsia and fetal growth restriction. Decades of research have not translated into a clear understanding of the underlying pathophysiologies or effective identification of women who are at high risk of developing these complications. Often the severity of these diseases does not correlate with the clinical symptoms, and current diagnostic methods are unable to accurately predict the conditions prior to clinical presentation. Though several potential markers have been proposed for each of these disorders, to date none have proven clinical utility. Emerging proteomic technology is only beginning to be employed in pregnancy research. A comprehensive analysis of gestational tissues can be expected to contribute to the elucidation of the complex molecular mechanisms of pregnancy and related complications. Comparison of the expression profiles of normal and pathogenic tissues and biofluids may also highlight novel candidate marker proteins that have so far remained undetected. More interestingly, rapidly evolving technologies using sophisticated bioinformatic tools are demonstrating their potential in disea...Continue Reading

Citations

Oct 13, 2012·Molecular & Cellular Proteomics : MCP·Shannon K Flood-NicholsDanielle L Ippolito
Apr 28, 2009·Current Opinion in Infectious Diseases·Catalin S BuhimschiIrina A Buhimschi
Dec 18, 2013·Cell Biochemistry and Biophysics·Kaidong MaXiaotian Li
May 27, 2015·International Journal of Molecular Sciences·Kai P LawPhilip N Baker
Jan 1, 2008·Expert Opinion on Medical Diagnostics·Cees Bm Oudejans
Oct 24, 2012·Clinical Biochemistry·Athanasios K Anagnostopoulos, George Th Tsangaris
Apr 14, 2005·Prenatal Diagnosis
Dec 17, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·R P HorganP N Baker
Aug 1, 2007·Proteomics. Clinical Applications·Aggeliki KolialexiGeorge Th Tsangaris
Jul 12, 2008·Mass Spectrometry Reviews·Aggeliki KolialexiGeorge Th Tsangaris
Jul 19, 2006·Proteomics·George Th TsangarisMichael Fountoulakis
Sep 1, 2007·Proteomics. Clinical Applications·Rose P Webster, Leslie Myatt
Jul 15, 2015·Disease Markers·Harry M GeorgiouShaun P Brennecke
May 7, 2011·Journal of Pregnancy·Jacqueline E A K Bamfo, Anthony O Odibo
Jun 2, 2015·Journal of Korean Medical Science·Jeong In YangHo Yeon Kim
Jan 11, 2014·Expert Review of Proteomics·Julie KleinJoost P Schanstra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
S P GygiR Aebersold
Mass Spectrometry Reviews
Aggeliki KolialexiGeorge Th Tsangaris
© 2022 Meta ULC. All rights reserved