Applications of reversible covalent chemistry in analytical sample preparation

The Analyst
David Siegel

Abstract

Reversible covalent chemistry (RCC) adds another dimension to commonly used sample preparation techniques like solid-phase extraction (SPE), solid-phase microextraction (SPME), molecular imprinted polymers (MIPs) or immuno-affinity cleanup (IAC): chemical selectivity. By selecting analytes according to their covalent reactivity, sample complexity can be reduced significantly, resulting in enhanced analytical performance for low-abundance target analytes. This review gives a comprehensive overview of the applications of RCC in analytical sample preparation. The major reactions covered include reversible boronic ester formation, thiol-disulfide exchange and reversible hydrazone formation, targeting analyte groups like diols (sugars, glycoproteins and glycopeptides, catechols), thiols (cysteinyl-proteins and cysteinyl-peptides) and carbonyls (carbonylated proteins, mycotoxins). Their applications range from low abundance proteomics to reversible protein/peptide labelling to antibody chromatography to quantitative and qualitative food analysis. In discussing the potential of RCC, a special focus is on the conditions and restrictions of the utilized reaction chemistry.

References

Jan 1, 1977·Analytical Biochemistry·S HigaY Yamamura
Aug 11, 1978·Journal of Chromatography·V K Akparov, V M Stepanov
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·H OkayamaO Hayaishi
Feb 1, 1975·Analytical Biochemistry·L J Lin, J F Foster
Mar 1, 1990·Journal of Clinical Microbiology·R BoomJ van der Noordaa
Jun 27, 1990·Journal of Chromatography·D J O'Shannessy
Feb 1, 1989·Analytical Biochemistry·S Oscarsson, J Porath
Jul 1, 1973·The Biochemical Journal·K BrocklehurstE M Crook
Jul 16, 1974·Biochemistry·J D Rawn, G E Lienhard
Jul 1, 1982·The Biochemical Journal·G T WilliamsP D Dean
Jul 15, 1984·The Biochemical Journal·S J Cartwright, S G Waley
Feb 1, 1981·Journal of Biochemical and Biophysical Methods·D A Hillson
May 13, 1993·Biochimica Et Biophysica Acta·T P Bradshaw, R B Dunlap
Feb 4, 1998·Analytical Biochemistry·B JerkovicP H Bolton
Apr 17, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·N V FedorovaO P Zhirnov
Jul 27, 1999·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·H H Barnes, C A Ishimaru
Aug 15, 2000·Journal of Chromatography. a·H Lord, J Pawliszyn
Sep 21, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·N DelaunayM C Hennion
Mar 28, 2001·Journal of Chromatography. a·Y C LiB Mattiasson
Apr 9, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kayo SakataKiyoshi Zaitsu
Jul 26, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·YuCai LiBo Mattiasson
Dec 20, 2002·Angewandte Chemie·Stuart J RowanJ Fraser Stoddart
May 15, 2003·Chemical Communications : Chem Comm·Régis Nguyen, Ivan Huc
Jul 25, 2003·Journal of Chromatography. a·Marie-Claire Hennion, Valérie Pichon
Oct 17, 2003·Angewandte Chemie·Claus JacobHelmut Sies
Jan 8, 2004·Journal of the American Chemical Society·Bhavana A DeoreMichael S Freund

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Citations

Apr 22, 2014·Analytical Chemistry·David SiegelRainer Bischoff
Dec 12, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·David SiegelRainer Bischoff
Jul 9, 2013·Mass Spectrometry Reviews·Maria FedorovaRalf Hoffmann
Oct 17, 2016·Journal of Chromatography. a·Cecilia RossettiTrine G Halvorsen
Nov 4, 2016·Chemical Communications : Chem Comm·Stacy L Capehart, Erin E Carlson
Mar 1, 2019·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Mahsa Sadat HosseininejadAhmad Jamshidi
May 15, 2018·Bioorganic & Medicinal Chemistry·Frederick M TomlinCarolyn R Bertozzi
Aug 10, 2021·Comprehensive Reviews in Food Science and Food Safety·Liang Chen, Philippe Darriet
Dec 15, 2016·Chemical Reviews·Krishnan K Palaniappan, Carolyn R Bertozzi
Aug 16, 2018·Journal of Agricultural and Food Chemistry·Mingming WangRuijin Yang
Apr 4, 2020·Journal of the American Chemical Society·Yuting XiongGuangyan Qing

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