Applied Machine Learning for Spine Surgeons: Predicting Outcome for Patients Undergoing Treatment for Lumbar Disc Herniation Using PRO Data

Global Spine Journal
Casper Friis PedersenSøren Eiskjær

Abstract

Retrospective/prospective study. Models based on preoperative factors can predict patients' outcome at 1-year follow-up. This study measures the performance of several machine learning (ML) models and compares the results with conventional methods. Inclusion criteria were patients who had lumbar disc herniation (LDH) surgery, identified in the Danish national registry for spine surgery. Initial training of models included 16 independent variables, including demographics and presurgical patient-reported measures. Patients were grouped by reaching minimal clinically important difference or not for EuroQol, Oswestry Disability Index, Visual Analog Scale (VAS) Leg, and VAS Back and by their ability to return to work at 1 year follow-up. Data were randomly split into training, validation, and test sets by 50%/35%/15%. Deep learning, decision trees, random forest, boosted trees, and support vector machines model were trained, and for comparison, multivariate adaptive regression splines (MARS) and logistic regression models were used. Model fit was evaluated by inspecting area under the curve curves and performance during validation. Seven models were arrived at. Classification errors were within ±1% to 4% SD across validation folds. ...Continue Reading

References

Nov 14, 2000·Spine·J C Fairbank, P B Pynsent
Oct 13, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Henrica C W de VetLex M Bouter
Oct 6, 2010·BMC Medical Research Methodology·Niels Smits
Jan 11, 2014·Frontiers in Neurorobotics·Alexey Natekin, Alois Knoll
Mar 13, 2014·Biometrical Journal. Biometrische Zeitschrift·Ewout W SteyerbergBen Van Calster
Dec 24, 2014·BMC Medical Research Methodology·Tjeerd van der PloegEwout W Steyerberg
May 29, 2015·Nature·Yann LeCunGeoffrey Hinton
Jul 26, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Karen HøjmarkM O Andersen
Sep 26, 2017·Emerging Themes in Epidemiology·Ashwini VenkatasubramaniamSimone French
Mar 14, 2018·JAMA : the Journal of the American Medical Association·Andrew L Beam, Isaac S Kohane
Jul 13, 2018·Frontiers in Bioengineering and Biotechnology·Federico CabitzaGiuseppe Banfi
Nov 20, 2018·The Spine Journal : Official Journal of the North American Spine Society·Victor E StaartjesMarc L Schröder
Feb 15, 2019·Journal of Clinical Epidemiology·Evangelia ChristodoulouBen Van Calster
Oct 28, 2019·Science·Ziad ObermeyerSendhil Mullainathan
Mar 15, 2020·Journal of Clinical Epidemiology·Simon NusinoviciChing-Yu Cheng

❮ Previous
Next ❯

Citations

Oct 12, 2021·Global Spine Journal·GuanRui RenXiaoTao Wu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.