Applying dimensional psychopathology: transdiagnostic associations among regional homogeneity, leptin and depressive symptoms.

Translational Psychiatry
Yan-Ge WeiFei Wang

Abstract

Dimensional psychopathology and its neurobiological underpinnings could provide important insights into major psychiatric disorders, including major depressive disorder, bipolar disorder and schizophrenia. In a dimensional transdiagnostic approach, we examined depressive symptoms and their relationships with regional homogeneity and leptin across major psychiatric disorders. A total of 728 participants (including 403 patients with major psychiatric disorders and 325 age-gender-matched healthy controls) underwent resting-state functional magnetic resonance imaging at a single site. We obtained plasma leptin levels and depressive symptom measures (Hamilton Depression Rating Scale (HAMD)) within 24 h of scanning and compared the regional homogeneity (ReHo), plasma leptin levels and HAMD total score and factor scores between patients and healthy controls. To reveal the potential relationships, we performed correlational and mediational analyses. Patients with major psychiatric disorders had significant lower ReHo in primary sensory and visual association cortices and higher ReHo in the frontal cortex and angular gyrus; plasma leptin levels were also elevated. Furthermore, ReHo alterations, leptin and HAMD factor scores had signific...Continue Reading

References

Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Aug 30, 2003·Biological Psychiatry·Mary L PhillipsRichard Lane
Apr 28, 2004·NeuroImage·Yufeng ZangLixia Tian
Jan 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xin-Yun LuWei Zhang
Jan 24, 2007·Biological Psychiatry·Stefan KloiberSusanne Lucae
Aug 31, 2007·Journal of Affective Disorders·Julie A PascoMichael Berk
Mar 10, 2009·Journal of Affective Disorders·Rudolf UherAnne Farmer
Jan 1, 2009·International Review of Psychiatry·Michèle Wessa, Julia Linke
Jul 3, 2010·The American Journal of Psychiatry·Thomas InselPhilip Wang
Jun 26, 2012·Neuron·Joshua W Buckholtz, Andreas Meyer-Lindenberg
Sep 26, 2012·Clinical Schizophrenia & Related Psychoses·Cherise RosenJohn A Sweeney
Feb 26, 2013·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Diana A ChirinosNeil Schneiderman
Mar 5, 2013·Lancet·UNKNOWN Cross-Disorder Group of the Psychiatric Genomics Consortium
Sep 3, 2013·NeuroImage·Jonathan D PowerSteven E Petersen
May 28, 2014·Journal of Chemical Neuroanatomy·Jeanette C Valleau, Elinor L Sullivan
Aug 6, 2014·Metabolism: Clinical and Experimental·Olivia M FarrChristos S Mantzoros
Feb 5, 2015·JAMA Psychiatry·Madeleine GoodkindAmit Etkin
Jul 15, 2015·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Lili Jiang, Xi-Nian Zuo
Sep 12, 2015·Psychoneuroendocrinology·Angela C Incollingo RodriguezA Janet Tomiyama
Dec 22, 2015·Journal of Chemical Neuroanatomy·John F SmileyAndrew J Dwork
Apr 15, 2016·Neuroinformatics·Chao-Gan YanYu-Feng Zang
Apr 26, 2016·Psychiatry Research·Daniel J NortonYue Chen
Feb 1, 2017·The American Journal of Psychiatry·Anup SharmaTheodore D Satterthwaite
May 4, 2017·JAMA Psychiatry·Julia M SheffieldDeanna M Barch
May 16, 2018·Biological Psychiatry·Laura H JacobsonJohn F Cryan

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay

Software Mentioned

DPABI
SPSS Statistics
Statistical Parametric Mapping 8 SPM8 Processing Assistant for
SPSS

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.