Applying Machine Learning Techniques to Identify Undiagnosed Patients with Exocrine Pancreatic Insufficiency

Journal of Health Economics and Outcomes Research
Bruce PyensonJaime Vora

Abstract

Exocrine pancreatic insufficiency (EPI) is a serious condition characterized by a lack of functional exocrine pancreatic enzymes and the resultant inability to properly digest nutrients. EPI can be caused by a variety of disorders, including chronic pancreatitis, pancreatic cancer, and celiac disease. EPI remains underdiagnosed because of the nonspecific nature of clinical symptoms, lack of an ideal diagnostic test, and the inability to easily identify affected patients using administrative claims data. To develop a machine learning model that identifies patients in a commercial medical claims database who likely have EPI but are undiagnosed. A machine learning algorithm was developed in Scikit-learn, a Python module. The study population, selected from the 2014 Truven MarketScan® Commercial Claims Database, consisted of patients with EPI-prone conditions. Patients were labeled with 290 condition category flags and split into actual positive EPI cases, actual negative EPI cases, and unlabeled cases. The study population was then randomly divided into a training subset and a testing subset. The training subset was used to determine the performance metrics of 27 models and to select the highest performing model, and the testing s...Continue Reading

References

Apr 21, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·J Enrique Domínguez-MuñozMarta Iglesias-Rey
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Nusrat ShafiqSamir Malhotra
Oct 20, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·John S LeedsDavid S Sanders
Oct 20, 2010·The Medical Journal of Australia·James ToouliUNKNOWN Australasian Pancreatic Club
Nov 17, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Luca FrulloniGiuseppe Zamboni
Jul 15, 2011·Clinical and Experimental Gastroenterology·Aaron FiekerMartine Armand
Oct 1, 2013·Journal of the American Medical Informatics Association : JAMIA·Danning HeSusan Hutfless
Nov 22, 2013·World Journal of Gastroenterology : WJG·Björn Lindkvist
Apr 1, 2013·United European Gastroenterology Journal·J-Matthias LöhrLuca Frulloni
Mar 10, 2015·Computational and Structural Biotechnology Journal·Konstantina KourouDimitrios I Fotiadis
Nov 20, 2015·International Journal of Radiation Oncology, Biology, Physics·John KangSushil Beriwal
Jun 23, 2016·American Journal of Clinical Pathology·Yuan LuoJason M Baron
Aug 30, 2016·The Lancet. Psychiatry·Jonathan YoungPhilip McGuire
Sep 20, 2016·EURASIP Journal on Bioinformatics & Systems Biology·Xia HuUNKNOWN ACT NOW Study Investigators
Dec 13, 2016·Transplantation·Lawrence LauJames Bailey
Feb 1, 2017·Computational and Structural Biotechnology Journal·Ioannis KavakiotisIoanna Chouvarda
Feb 12, 2017·BMC Medicine·Maarten R StruyvenbergSteven D Freedman
May 13, 2017·Journal of Diabetes Science and Technology·Arianna DagliatiRiccardo Bellazzi
Jun 22, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·João Ricardo SatoRodrigo Affonseca Bressan
Jul 1, 2017·Investigative Ophthalmology & Visual Science·Hrvoje BogunovicUrsula Schmidt-Erfurth
Jul 12, 2017·BMC Psychiatry·Glenn N SaxeConstantin Aliferis
Jul 12, 2017·Journal of Medical Internet Research·Qijin ChengPaul Sf Yip
Jul 13, 2017·Social Psychiatry and Psychiatric Epidemiology·Sheshadri Iyengar Raghavan BhagyashreeMurali Krishna

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Methods Mentioned

BETA
pancreatectomy

Software Mentioned

LASSO
Scikit
PERT
learn
MarketScan

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