Applying Multivalent Biomolecular Interactions for Biosensors

Chemistry : a European Journal
Hyeongjoo Choi, Yongwon Jung

Abstract

Multivalent interactions between more than one interconnected biomolecule are easily found in diverse natural systems. With the cooperation of many interacting pairs, this clustered binding can achieve highly enhanced affinities. Whereas the binding of an individual pair remains reversible, the binding between multivalent biomolecules can become nearly irreversible. Although the underlying principles of the multivalent effect have yet to be revealed, this intriguing concept of multivalent interaction has been widely applied to diverse fields. Multivalency has become a key strategy to increase the potency of inhibitors against target pathogens and, more recently, enhanced target binding by multivalency has offered an attractive strategy for biosensing. In this article, the current status of multivalent interaction studies and their progress in the biosensing area will be discussed.

References

Jan 20, 1998·Journal of Immunological Methods·T O'Connor, J P Gosling
Mar 25, 2006·Angewandte Chemie·Laura L KiesslingLaura E Strong
Feb 1, 2007·Journal of the American Chemical Society·Vijay M KrishnamurthyGeorge M Whitesides
Apr 8, 2009·Nature Nanotechnology·Jin-Seung ParkJeewon Lee
May 6, 2009·Angewandte Chemie·Hans-Jörg Schneider
Sep 25, 2010·Biosensors & Bioelectronics·Yanyan WangXiangqun Zeng
May 18, 2011·Chemical Society Reviews·Paolo Scrimin, Leonard J Prins
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Francisco J Martinez-Veracoechea, Daan Frenkel
Sep 7, 2012·Angewandte Chemie·Carlo FastingRainer Haag
Apr 10, 2013·Journal of the American Chemical Society·Eva Maria MunozEduardo Fernandez-Megia
Apr 15, 2014·Molecular Pharmaceutics·Mallory A van DongenMark M Banaszak Holl
Jul 26, 2014·Chemical Society Reviews·Chunhua RenZhimou Yang
Nov 27, 2014·Biomacromolecules·Chad T VarnerRavi S Kane
Jan 16, 2015·International Journal of Molecular Sciences·Pamela T Wong, Seok Ki Choi
Jan 28, 2015·Journal of the American Chemical Society·Jonathan VonnemannRainer Haag
Jan 31, 2015·Cell·Rachel P GalimidiPamela J Bjorkman
Apr 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Galina V DubachevaRalf P Richter
Jul 1, 2015·Beilstein Journal of Organic Chemistry·Susanne Liese, Roland R Netz
Jul 4, 2015·Biosensors & Bioelectronics·Yeon Seok KimMan Bock Gu
Jan 23, 2016·Chemical Reviews·Guanying ChenParas N Prasad
Feb 11, 2016·Computational and Structural Biotechnology Journal·Jacinto López-SagasetaMatthew J Bottomley
Mar 12, 2016·Organic & Biomolecular Chemistry·Yu-Na Kim, Yongwon Jung
Jun 25, 2016·Journal of the American Chemical Society·Sumati BhatiaRainer Haag
Jul 2, 2016·Essays in Biochemistry·Shikha SharmaRichard J O'Kennedy
Nov 8, 2016·Biosensors & Bioelectronics·Masumi Iijima, Shun'ichi Kuroda
Feb 23, 2017·Nature Reviews. Molecular Cell Biology·Salman F BananiMichael K Rosen
Apr 12, 2017·Bioconjugate Chemistry·Ming-Hsin LiJames R Baker
May 16, 2017·Angewandte Chemie·Takuya MachidaNicolas Winssinger
Sep 25, 2017·Science·Yongdae Shin, Clifford P Brangwynne
Nov 4, 2017·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·M D Shahinuzzaman, Dipak Barua
Apr 1, 2018·Angewandte Chemie·Qi LiuChunhai Fan

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