Applying nanomedicine in maladaptive inflammation and angiogenesis

Advanced Drug Delivery Reviews
Amr AlaargWillem J M Mulder

Abstract

Inflammation and angiogenesis drive the development and progression of multiple devastating diseases such as atherosclerosis, cancer, rheumatoid arthritis, and inflammatory bowel disease. Though these diseases have very different phenotypic consequences, they possess several common pathophysiological features in which monocyte recruitment, macrophage polarization, and enhanced vascular permeability play critical roles. Thus, developing rational targeting strategies tailored to the different stages of the journey of monocytes, from bone marrow to local lesions, and their extravasation from the vasculature in diseased tissues will advance nanomedicine. The integration of in vivo imaging uniquely allows studying nanoparticle kinetics, accumulation, clearance, and biological activity, at levels ranging from subcellular to an entire organism, and will shed light on the fate of intravenously administered nanomedicines. We anticipate that convergence of nanomedicines, biomedical engineering, and life sciences will help to advance clinically relevant therapeutics and diagnostic agents for patients with chronic inflammatory diseases.

References

Jul 8, 2016·Nature Reviews. Rheumatology·Irina A UdalovaMarc Feldmann

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Citations

Aug 31, 2018·Cardiovascular Research·Iwona CichaDidier Letourneur
Aug 14, 2019·Advanced Science·Huize YanKam W Leong
Aug 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Harald Mangge, Gunter Almer
Apr 8, 2020·Frontiers in Bioengineering and Biotechnology·Chen-Wen LiWan-Liang Lu
Jun 25, 2020·Cells·Valentina Dallacasagrande, Katherine A Hajjar
Feb 5, 2021·Archives of Pharmacal Research·Jongyoon ShinnYonghyun Lee
Apr 20, 2021·Advanced Healthcare Materials·Long ChenHai-Quan Mao
May 26, 2021·Advanced Drug Delivery Reviews·Elias Fattal, François Fay
Jul 13, 2021·Signal Transduction and Targeted Therapy·Huakan ZhaoYongsheng Li
Dec 2, 2021·Cardiovascular Research·Qiuyu Martin ZhuPatrick T Ellinor

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