Applying novel genome-wide linkage strategies to search for loci influencing type 2 diabetes and adult height in American Samoa.

Human Biology
Karolina AbergDaniel E Weeks

Abstract

Type 2 diabetes mellitus (T2DM) is a common complex phenotype that by the year 2010 is predicted to affect 221 million people globally. In the present study we performed a genome-wide linkage scan using the allele-sharing statistic Sall implemented in Allegro and a novel two-dimensional genome-wide strategy implemented in Merloc that searches for pairwise interaction between genetic markers located on different chromosomes linked to T2DM. In addition, we used a robust score statistic from the newly developed QTL-ALL software to search for linkage to variation in adult height. The strategies were applied to a study sample consisting of 238 sib-pairs affected with T2DM from American Samoa. We did not detect any genome-wide significant susceptibility loci for T2DM. However, our two-dimensional linkage investigation detected several loci pairs of interest, including 11q22 and 21q21, 9q21 and 11q22, 1p22-p21 and 4p15, and 4p15 and 15q11-q14, with a two-loci maximum LOD score (MLS) greater than 2.00. Most detected individual loci have previously been identified as susceptibility loci for diabetes-related traits. Our two-dimensional linkage results may facilitate the selection of potential candidate genes and molecular pathways for fu...Continue Reading

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Citations

Jun 6, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Rongrong ChenLusheng Huang
Jul 23, 2009·Current Opinion in Pediatrics

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Methods Mentioned

BETA
Genotyping
Profiler

Software Mentioned

Merlin
Merloc
Allegro
QTL
Mendel
PedCheck
R
Mega2
ALL
RelPair

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