Applying saccade models to account for oscillations

Progress in Brain Research
Stefano RamatL M Optican

Abstract

Saccadic oscillations are unwanted back-to-back saccades occurring one upon the other that produce a high-frequency oscillation of the eyes (usually 15-30 Hz). These may occur transiently in normal subjects, for example, around the orthogonal axis of a purely horizontal or vertical saccade, during combined saccade-vergence gaze shifts or during blinks. Some subjects may produce saccadic oscillations at will, usually with convergence. Pathological, involuntary saccadic oscillations such as flutter and opsoclonus are prominent in certain diseases. Our recent mathematical model of the premotor circuit for generating saccades includes brainstem burst neurons in the paramedian pontine reticular formation (PPRF), which show the physiological phenomenon of post-inhibitory rebound (PIR). This model makes saccadic oscillations because of the positive feedback among excitatory and inhibitory burst neurons. Here we review our recent findings and hypotheses and show how they may be reproduced using our lumped model of the saccadic premotor circuitry by reducing the inhibitory efficacy of omnipause neurons.

References

May 1, 1979·Annals of Neurology·D S Zee, D A Robinson
Aug 1, 1977·Archives of Ophthalmology·W T ShultsA L Ochs
Feb 1, 1991·Brain : a Journal of Neurology·J AsheN J Schatz
Jul 15, 1986·The Journal of Comparative Neurology·A StrassmanR A McCrea
Jul 15, 1986·The Journal of Comparative Neurology·A StrassmanR A McCrea
Mar 1, 1986·Annals of Neurology·T C HainM Mordes
Jan 1, 1996·Annual Review of Physiology·J R Huguenard
Sep 6, 2001·Journal of the Neurological Sciences·A M WongJ A Sharpe
Dec 31, 2002·Physiological Reviews·Edward Perez-Reyes
Mar 29, 2003·Neural Networks : the Official Journal of the International Neural Network Society·Philippe LefèvreLance M. Optican
Aug 4, 2004·Experimental Brain Research·Stefano RamatLance M Optican
May 10, 2007·Journal of Neurophysiology·Yoshiko IzawaYoshikazu Shinoda
Jan 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jean-Marc IsraelStéphane H R Oliet
Oct 10, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M ManconiL Ferini-Strambi

❮ Previous
Next ❯

Citations

Aug 25, 2015·Journal of Neuroimmunology·Jessica A PanzerDavid R Lynch
Dec 15, 2010·Current Opinion in Neurology·Alessandro SerraR John Leigh
Jan 8, 2015·Experimental Brain Research·Fatema F Ghasia, Aasef G Shaikh
Apr 19, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Palak Gupta, Aasef G Shaikh
Sep 29, 2011·Annals of the New York Academy of Sciences·Susan A KingR John Leigh
Jun 13, 2018·Frontiers in Neurology·Jorge Otero-MillanSusana Martinez-Conde
Aug 24, 2018·The Cerebellum·Daniel FeldmanAasef G Shaikh
Dec 30, 2016·Brain : a Journal of Neurology·Florian SchöberlAndreas Zwergal
Jan 1, 2017·Expert Review of Ophthalmology·Sushant Puri, Aasef G Shaikh
Jan 21, 2016·Journal of Clinical Movement Disorders·Pichet TermsarasabSteven J Frucht
Apr 12, 2021·Journal of Computational Neuroscience·Janet C RuckerLance M Optican

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
Aasef G ShaikhDavid S Zee
Brain : a Journal of Neurology
J AsheN J Schatz
Vision Research
Aasef G ShaikhDavid S Zee
© 2022 Meta ULC. All rights reserved