Applying terahertz technology for nondestructive detection of crack initiation in a film-coated layer on a swelling tablet

Results in Pharma Sciences
Wataru MomoseKatsuhide Terada

Abstract

Here, we describe a nondestructive approach using terahertz wave to detect crack initiation in a film-coated layer on a drug tablet. During scale-up and scale-down of the film coating process, differences in film density and gaps between the film-coated layer and the uncoated tablet were generated due to differences in film coating process parameters, such as the tablet-filling rate in the coating machine, spray pressure, and gas-liquid ratio etc. Tablets using the PEO/PEG formulation were employed as uncoated tablets. We found that heat and humidity caused tablets to swell, thereby breaking the film-coated layer. Using our novel approach with terahertz wave nondestructively detect film surface density (FSD) and interface density differences (IDDs) between the film-coated layer and an uncoated tablet. We also found that a reduced FSD and IDD between the film-coated layer and uncoated tablet increased the risk of crack initiation in the film-coated layer, thereby enabling us to nondestructively predict initiation of cracks in the film-coated layer. Using this method, crack initiation can be nondestructively assessed in swelling tablets after the film coating process without conducting accelerated stability tests, and film coatin...Continue Reading

Citations

Nov 18, 2014·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Wanli TuLigang Yao
Jan 5, 2016·Drug Development and Industrial Pharmacy·Yan YangHai-Ning Yu
Feb 27, 2014·Pharmaceutical Research·Masahiro NiwaKatsuhide Terada
Aug 2, 2016·Chemical & Pharmaceutical Bulletin·Hiroyuki YoshinoShigeru Itai
Mar 12, 2020·Sensors·Décio Alves-LimaHungyen Lin

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