Appraising MicroRNA-155 as a Noninvasive Diagnostic Biomarker for Cancer Detection: A Meta-Analysis

Medicine
Yi HouZhiying Chen

Abstract

Cancer has been a major public health issue all over the world and cancer patients diagnosed at early stages have a comparatively favorable prognosis. The association between specific dysregulated expressed microRNA-155 (miRNA-155, miR-155) and tumorigenesis has been identified by numerous studies. However, perplexity and inconsistence arise from a wide range of studies due to heterogeneity. Therefore, this meta-analysis was carried out to validate the association between miR-155 and tumorigenesis together with the clinical applicability of miR-155.Relevant studies were searched, identified, and selected from PubMed, Embase, Cochrane, Sinomed, and Wanfang database until July 5, 2015. Then, the sensitivity, specificity, and area under the summary receiver operator characteristic curve (AUC) were calculated to assess the overall performance miR-155 for cancer detection.A total of 25 studies were included in the meta-analysis with a total number of 1896 cancer patients and 1226 healthy controls. The overall sensitivity and specificity was 76.8% (95%CI: 71.1-81.7%) and 82.9% (95% CI: 77.5-87.3%), respectively. In addition, the pooled AUC and partial AUC was 0.867 and 0.718, respectively. Results from subgroup analyses suggested tha...Continue Reading

References

Nov 15, 2003·Journal of Clinical Epidemiology·Afina S GlasPatrick M M Bossuyt
Feb 10, 2006·JAMA : the Journal of the American Medical Association·Jaime L PetersLesley Rushton
May 16, 2006·Biostatistics·Roger M HarbordJonathan A C Sterne
Sep 23, 2006·Developmental Biology·Baohong ZhangTodd A Anderson
Apr 3, 2008·Annals of Medicine·Douglas J Guarnieri, Ralph J DiLeone
Dec 25, 2008·Cancer Biology & Therapy·Nils HabbeAnirban Maitra
May 19, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ying XieFeng Jiang
Oct 9, 2009·International Reviews of Immunology·Esmerina TiliJean-Jacques Michaille
Jan 12, 2011·Journal of Translational Medicine·Tom DonnemLill-Tove Busund
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Lei YuFeng Jiang
May 6, 2011·International Journal of Cancer. Journal International Du Cancer·Niels H H HeegaardCurtis C Harris
May 19, 2011·Cancer Research·Thalia A FaraziThomas Tuschl
Jun 21, 2011·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Oct 12, 2011·Annals of Hematology·Cheng FangJian-Yong Li
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Aug 4, 2012·PloS One·Kai WangDavid J Galas
Aug 16, 2012·Journal of Toxicology and Environmental Health. Part a·Ran LiuLihong Yin
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 7, 2013·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Dongfang TangYongjie Wang
Apr 6, 2013·Cell Biochemistry and Biophysics·Amal A Abd-El-FattahMariam Lotfy Aboulftouh
Jul 3, 2013·Japanese Journal of Clinical Oncology·Yan WangMing Chu
Sep 13, 2013·Cancer Biology & Therapy·Xiong LiuXiang-Ping Li
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 21, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Yan-Hong NiQin-Gang Hu
May 21, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Faliang WangXian Wang
Dec 22, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhong-chuan LvDa-wei Zhao
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Oct 1, 2016·Molecular Diagnosis & Therapy·Jonathan R ThompsonLiang Wang
Jan 24, 2019·Biomarkers in Medicine·Ziba Nariman-Saleh-FamJavad Tavakkoli-Bazzaz
Dec 8, 2016·Biomarkers in Medicine·Yu-Qing HuangYing-Qing Feng
Mar 29, 2019·Mediators of Inflammation·Frank TackeTom Luedde
Jan 22, 2021·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Xuemin LiuYikun Jiang

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase

Software Mentioned

R
QUADAS

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Lihua LiuJianchao Liu
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Faliang WangXian Wang
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Ronghe GuZhonggui Huang
International Journal of Clinical and Experimental Medicine
Shan JinHang Li
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Lijun ShenShaojie Xin
© 2022 Meta ULC. All rights reserved