Apr 18, 2020

Transient disruption of the inferior parietal lobule impairs the ability to attribute intention to action

BioRxiv : the Preprint Server for Biology
J.-F. PatriC. Becchio

Abstract

Although it is well established that fronto-parietal regions are active during action observation, whether they play a causal role in the ability to infer intentions of others from visual kinematics remains undetermined. In experiments reported here, we combined offline continuous theta-burst stimulation (cTBS) with computational modeling to reveal single-trial computations in the inferior parietal lobule (IPL) and inferior frontal gyrus (IFG). Participants received cTBS over the left anterior IPL and the left IFG pars orbitalis, in separate sessions, before completing an intention discrimination task (discriminate intention of observed reach-to-grasp acts) or a kinematic discrimination task (discriminate peak wrist height of the same acts) unrelated to intention. We targeted intentions-sensitive regions whose fMRI-measured activity accurately discriminated intention from the same action stimuli. We found that transient disruption of activity of the left IPL, but not the IFG, impaired the ability of the observers to judge intention from movement kinematics. Kinematic discrimination unrelated to intention, in contrast, was largely unaffected. Computational analyses revealed that IPL cTBS did not impair the ability to see changes...Continue Reading

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Mentioned in this Paper

Research Subject
Approach
Cognition
Silo (Dataset)
Sampling - Surgical Action
Protein Expression

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