Approach to diagnosis and management of myeloproliferative neoplasm variants

[Rinshō ketsueki] The Japanese journal of clinical hematology
Toru Mitsumori, Keita Kirito

Abstract

Myeloproliferative neoplasm (MPN) variants are defined as relatively uncommon myeloid neoplasms which do not meet the criteria for either classical MPN or myelodysplastic syndrome. Due to the lack of specific markers, it has been challenging to accurately diagnose these malignant diseases. Recent studies have revealed new genetic abnormalities in MPN variants. These research advances are anticipated to open new approaches to not only achieving accurate diagnosis but also novel therapeutic options for these diseases.

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