Approach to record linkage of primary care data from Clinical Practice Research Datalink to other health-related patient data: overview and implications

European Journal of Epidemiology
Shivani PadmanabhanHelen Strongman

Abstract

Record linkage is increasingly used to expand the information available for public health research. An understanding of record linkage methods and the relevant strengths and limitations is important for robust analysis and interpretation of linked data. Here, we describe the approach used by Clinical Practice Research Datalink (CPRD) to link primary care data to other patient level datasets, and the potential implications of this approach for CPRD data analysis. General practice electronic health record software providers separately submit de-identified data to CPRD and patient identifiers to NHS Digital, excluding patients who have opted-out from contributing data. Data custodians for external datasets also send patient identifiers to NHS Digital. NHS Digital uses identifiers to link the datasets using an 8-stage deterministic methodology. CPRD subsequently receives a de-identified linked cohort file and provides researchers with anonymised linked data and metadata detailing the linkage process. This methodology has been used to generate routine primary care linked datasets, including data from Hospital Episode Statistics, Office for National Statistics and National Cancer Registration and Analysis Service. 10.6 million (M) pa...Continue Reading

References

Sep 10, 1999·American Journal of Hypertension·E Degli EspostiA Sturani
Jul 27, 2002·Australian and New Zealand Journal of Public Health·C W KelmanC D J Holman
Jan 20, 2009·BMC Medical Informatics and Decision Making·Ronan A LyonsKen Leake
Apr 7, 2010·Journal of Evaluation in Clinical Practice·Ileana BaldiDario Gregori
Dec 24, 2010·BMC Health Services Research·Megan A BohenskyCaroline A Brand
Oct 7, 2011·Australian and New Zealand Journal of Public Health·Megan A BohenskyCaroline Brand
Jun 19, 2012·Journal of Epidemiology and Community Health·Katie HarronRuth Gilbert
May 26, 2015·Journal of Biomedical Informatics·Ying ZhuSoko Setoguchi
Jun 8, 2015·International Journal of Epidemiology·Emily HerrettLiam Smeeth
Jul 3, 2015·Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention·Ruth BakerElizabeth Orton
Aug 9, 2015·BMC Health Services Research·James H BoydJames B Semmens
Oct 7, 2015·PLoS Medicine·Eric I BenchimolUNKNOWN RECORD Working Committee
Dec 17, 2015·Annual Review of Public Health·Joan A CaseyNancy E Adler
Dec 22, 2015·International Journal of Epidemiology·Adrian SayersFiona Steele
Jan 19, 2016·Journal of Clinical Epidemiology·Elizabeth R C MillettSara L Thomas
Feb 3, 2016·Journal of Clinical Epidemiology·Cecilia L MooreJanaki Amin
Oct 21, 2016·PloS One·Katie HarronJan van der Meulen
Dec 7, 2016·Clinical Epidemiology·Kieran J RothnieJennifer K Quint
Apr 4, 2017·Journal of Public Health·Ruth GilbertHarvey Goldstein
Dec 12, 2018·International Journal of Population Data Science·J C Doidge, K Harron

❮ Previous
Next ❯

Citations

May 14, 2019·Clinical Trials : Journal of the Society for Clinical Trials·Qinli MaKevin Haynes
Jan 18, 2020·Pharmacoepidemiology and Drug Safety·Donna R RiveraSudha R Raman
Feb 15, 2020·Journal of Comparative Effectiveness Research·Cormac J SammonSreeram Ramagopalan
Jun 19, 2019·Therapeutic Advances in Drug Safety·Rebecca E GhoshRachael Williams
May 6, 2020·European Journal of Epidemiology·M Arfan IkramTrudy Voortman
Apr 18, 2019·Pharmacoepidemiology and Drug Safety·Helen StrongmanJanet Valentine
Mar 13, 2019·International Journal of Epidemiology·Achim WolfPuja Myles
Oct 23, 2020·Pharmacoepidemiology and Drug Safety·Alejandro AranaSusana Perez-Gutthann
Jan 12, 2021·Pharmacoepidemiology and Drug Safety·Vanessa C BrunettiKristian B Filion
Dec 12, 2020·BMC Medical Research Methodology·Holly TibbleUNKNOWN Salford Lung Study Team
Jan 24, 2021·International Journal of Medical Informatics·Debbie VermondDorien L M Zwart
Feb 16, 2021·Journal of Orthopaedic Trauma·David J HakChristina D Mack
Apr 21, 2021·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Garth FunstonFiona M Walter
Apr 19, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Isabelle DurieuManon Belhassen
Jun 24, 2021·Seizure : the Journal of the British Epilepsy Association·Richard F M ChinRowena Holland
Aug 19, 2021·The Lancet Regional Health. Europe·Sheng-Chia ChungRui Providencia
Sep 13, 2021·British Journal of Clinical Pharmacology·Giovanna CuledduDyfrig A Hughes

❮ Previous
Next ❯

Software Mentioned

SAIL
CPRD
PHARMO

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.