Approach to tapering antisarcoidosis therapy

Current Opinion in Pulmonary Medicine
Kamonpun Ussavarungsi, Alicia K Gerke

Abstract

Sarcoidosis is a multisystemic granulomatous disease, which commonly affects the lung. The natural course of the disease and prognosis are variable from asymptomatic, spontaneous remission to progressive disease, which requires treatment. Once treatment is initiated, tapering therapy can be problematic. Corticosteroids are recommended as first-line therapy, but optimal regimen and duration of treatment is not well established. Treatment may differ based on severity of disease, extrapulmonary involvement, physician and patient preferences. We reviewed currently recommended regimens, particularly, in pulmonary sarcoidosis and the use of alternative treatments as corticosteroid-sparing agents. Corticosteroid use is quite effective as initial therapy but is associated with significant side effects. An approach to tapering sarcoidosis therapy is not standardized, given the lack of evidence-based data. This review provides guidance based on the current literature.

References

Apr 1, 1994·American Journal of Respiratory and Critical Care Medicine·G W HunninghakeD Schwartz
Jun 1, 1993·The American Review of Respiratory Disease·O P Sharma
Sep 2, 2006·The European Respiratory Journal·J C Grutters, J M M van den Bosch
Oct 24, 2007·Respiratory Medicine·Shanthi Paramothayan, Toby Lasserson
Jun 10, 2008·Clinics in Chest Medicine·Alicia K Gerke, Gary Hunninghake
Dec 10, 2009·The American Journal of the Medical Sciences·Brian P McKinzieMarc A Judson
Jan 22, 2010·Respiratory Medicine·Amanda C SchuttMarc A Judson
Nov 3, 2010·American Journal of Respiratory and Critical Care Medicine·Robert P BaughmanMarc A Judson
May 14, 2011·The European Respiratory Journal·D H SahooD A Culver
Oct 4, 2012·Chest·Efstratios Panselinas, Marc A Judson
Mar 30, 2013·Chest·Adriane D M VorselaarsJan C Grutters
Aug 31, 2013·The European Respiratory Journal·Adriane D M VorselaarsJan C Grutters
Feb 4, 2014·The European Respiratory Journal·Robert P Baughman, Marc A Judson
Oct 11, 2014·Respiratory Medicine·Nabeel HamzehLisa A Maier
May 2, 2015·The European Respiratory Journal·Adriane D M VorselaarsJan C Grutters
Jul 25, 2015·The Lancet. Respiratory Medicine·Robert P Baughman, Jan C Grutters
Nov 8, 2016·Expert Opinion on Pharmacotherapy·Pilar Brito-ZerónUNKNOWN SarcoGEAS-SEMI Study Group
Dec 13, 2017·Respiratory Medicine·Nauman A KhanDaniel A Culver
Jan 20, 2018·The European Respiratory Journal·Caroline E BroosBernt van den Blink
Jan 27, 2018·The European Respiratory Journal·Jonas Christian SchuppJoachim Müller-Quernheim
Sep 15, 2018·Journal of Asthma and Allergy·David B PriceTrung N Tran
Nov 18, 2018·Seminars in Arthritis and Rheumatism·Brandon L AdlerApril W Armstrong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Pulmonary Medicine
Kamonpun Ussavarungsi, Alicia K Gerke
American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions
Piera Fazzi
The Medical Clinics of North America
Nabeel Hamzeh
Seminars in Respiratory and Critical Care Medicine
Marc A Judson
BMJ : British Medical Journal
Daniel A Culver, Marc A Judson
© 2021 Meta ULC. All rights reserved