Approach to the complications of treatment for acute leukemia in the elderly

Seminars in Hematology
Joel Gingerich, Eric J Bow

Abstract

Acute leukemia is common in the elderly and, due to the aging population and poorer prognosis, represents a major challenge. Elderly acute leukemia patients have been arbitrarily defined as >or=55 to 65 years of age and are underrepresented in clinical trials. There are physiologic differences between elderly and non-elderly patients. A comprehensive understanding of these differences allows the development of a systematic approach to assessing the risks for treatment-related complications. Use of a comprehensive geriatric assessment (CGA), initially developed and validated in the general geriatric population, may allow more accurate assessment of the likelihood of chemotherapy-induced complications and allow for proactive risk minimization. Once complications to therapy develop, aggressive treatment is essential. Treatment related to common complications that arise from therapy will be reviewed. Further research directed at this population is required.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jun 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L S EltingB H Keefe
Feb 1, 1991·Journal of the American Geriatrics Society·D Podsiadlo, S Richardson
May 1, 1990·Annals of Internal Medicine·M S LachsM E Tinetti
Apr 1, 1984·Annals of Internal Medicine·S G BarnesJ O Ballard
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C ViscoliJ Klastersky
Jan 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P Y BochudP Francioli
Oct 1, 1994·Cancer·E L TrimbleM A Friedman
Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D F CellaJ Brannon
Jul 1, 1996·Annals of Internal Medicine·K ShanJ B Young
Apr 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E J BowB A Schacter
Apr 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R B Geller
Oct 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M CrucianiE Concia
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E J BowB Schacter
Aug 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L S EltingG P Bodey
Mar 21, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E A EngelsM Barza
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M ExtermannL Balducci
Jun 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J M Rowe
Nov 3, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L GomezK V Rolston
Aug 12, 1999·Journal of the American Geriatrics Society·D HamermanD Silver
Dec 30, 1999·The New England Journal of Medicine·L F HutchinsK S Albain
Feb 19, 2000·Hematology/oncology Clinics of North America·L Balducci, M B Corcoran
Jul 8, 2000·The Oncologist·L Balducci, M Extermann
Aug 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J KlasterskyJ Talcott
Oct 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H OzerUNKNOWN American Society of Clinical Oncology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

© 2022 Meta ULC. All rights reserved