Approach to the management of patients with chronic hepatitis C who failed to achieve sustained virologic response

Infectious Disease Clinics of North America
Amrita Sethi, Mitchell L Shiffman

Abstract

The combination of PEGIFN and RBV is the most effective therapy for patients with chronic hepatitis C. Although more than half of all patients are able to achieve SVR, a significant proportion of patients, particularly those with genotype 1, fail to have undetectable HCV RNA during treatment or relapse after completing therapy with return of detectable HCV RNA. An approach in the management of these patients is to identify factors that could have led to the NR or relapse and that could be corrected before or during a second course of therapy. Because fibrosis progression occurs slowly over decades for many patients with chronic hepatitis C, avoiding alcohol or other factors that could lead to fibrosis progression may be sufficient for the vast majority of patients. Other options that could be considered in patients who have more advanced disease include retreating with one of several new antiviral agents; retreating with higher doses of IFN or PEGIFN and RBV; or using IFN, PEGIFN, or RBV monotherapy long-term as maintenance therapy. The safety and efficacy of these approaches is being evaluated in numerous clinical trials.

References

Dec 18, 1986·The New England Journal of Medicine·J H HoofnagleE A Jones
Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L BoksH H Van Vliet
Dec 15, 1995·Annals of Internal Medicine·A M Di BisceglieJ H Hoofnagle
Jun 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M YanoK Okuda
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K L Lindsay
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E J HeathcoteL M Blatt
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T E WileyT J Layden
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L De FranceschiR Corrocher
Jun 28, 2000·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·C LoguercioC del VecchioBlanco
Dec 7, 2000·The New England Journal of Medicine·S ZeuzemM J Brunda
Dec 7, 2000·The New England Journal of Medicine·E J HeathcoteJ De Pamphilis
Feb 15, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K R ReddyJ DePamphilis
Apr 9, 2001·Clinics in Liver Disease·C Morishima, D R Gretch
Aug 2, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K L LindsayUNKNOWN Hepatitis Interventional Therapy Group
Oct 30, 2001·Journal of Clinical Microbiology·F S NolteD R Gretch
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Beat HelblingUNKNOWN Investigators of the Swiss Association for the Study of the Liver
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karen L Lindsay
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gary L Davis
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brian R Edlin
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marion G Peters, Norah A Terrault
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·John G McHutchison, Keyur Patel
Feb 19, 2003·Journal of Clinical Gastroenterology·Renuka Bhattacharya, Margaret C Shuhart
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jay H HoofnagleT Jake Liang
Aug 21, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jonathan C AndersonKandace J Williams
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gary L DavisJanice Albrecht
Mar 27, 2004·Alimentary Pharmacology & Therapeutics·G Reiss, E B Keeffe
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Doris B StraderUNKNOWN American Association for the Study of Liver Diseases
Apr 15, 2004·Gastroenterology Clinics of North America·Peter Hauser
May 28, 2004·The New England Journal of Medicine·Andrew J MuirUNKNOWN Atlantic Coast Hepatitis Treatment Group
Aug 21, 2004·Journal of Clinical Gastroenterology·Zobair M YounossiRoy Ferguson
Aug 28, 2004·Clinics in Liver Disease·Paul HaynesNaga Chalasani
Sep 4, 2004·Seminars in Liver Disease·Nezam H Afdhal
Sep 4, 2004·Seminars in Liver Disease·Andrea Ferreira-Gonzalez, Mitchell L Shiffman
Sep 4, 2004·Seminars in Liver Disease·Richard K Sterling, Mark S Sulkowski
Sep 7, 2004·Seminars in Liver Disease·Kamran Safdar, Eugene R Schiff

❮ Previous
Next ❯

Citations

Oct 3, 2012·The Science of the Total Environment·Louise CamenzuliKonrad Hungerbühler

❮ Previous
Next ❯

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.