Approaches to the development of new antituberculosis drugs

Reviews of Infectious Diseases
P Sensi

Abstract

In the last two decades, no new major antituberculosis drug has been developed. Although dramatic improvements in chemotherapy for tuberculosis have been achieved through careful studies of drug regimens, there is still a need for new agents that are highly active. The antimycobacterial drugs used at present in therapy for tuberculosis were obtained by either blind screening or chemical modification of active compounds, with tentative optimization of chemotherapeutic properties. Other approaches based on knowledge of the biochemistry of the mycobacterial cell should be tried. Certain constituents of the cell, such as mycolic acids, arabinogalactan, peptidoglycan, and mycobactins, may represent specific targets for new antituberculosis drugs. Products interfering with the biosynthesis of these mycobacterial constituents can be expected to show specific activity against these microorganisms, with no effect on the normal bacterial flora.

Citations

Aug 7, 2014·The Journal of Antibiotics·Giovanna Riccardi, Maria Rosalia Pasca
Jan 1, 1994·The Journal of Infection·A D RussellP A Jenkins
Sep 22, 2016·International Journal of Mycobacteriology·Joseph Mwanzia NgutaPhyllis G A Addo
Aug 1, 1997·Expert Opinion on Investigational Drugs·I Chopra
Jan 1, 1994·The Annals of Pharmacotherapy·C A Peloquin, S E Berning
Aug 21, 2001·Journal of the American Academy of Dermatology·L Requena, E Sánchez Yus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.