Approaches to the Pharmacological Management of Jet Lag

Drugs
Josephine Arendt

Abstract

For many years now a treatment mitigating the debilitating effects of jet lag has been sought. Rapid travel across time zones leads, in most people, to temporary symptoms, in particular poor sleep, daytime alertness and poor performance. Mis-timed circadian rhythms are considered to be the main factor underlying jet-lag symptoms, together with the sleep deprivation from long haul flights. Virtually all aspects of physiology are rhythmic, from cells to systems, and circadian rhythms are coordinated by a central pacemaker or clock in the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN adapts slowly to changes in time zone, and peripheral clocks or oscillators adapt at different rates, such that the organism is in a state of desynchrony from the external environment and internally. Light exposure is the main factor controlling the circadian system and needs to be considered together with any pharmacological interventions. This review covers the relatively new chronobiotic drugs, which can hasten adaptation of the circadian system, together with drugs directly affecting alertness and sleep propensity. No current treatment can instantly shift circadian phase to a new time zone; however, adaptation can be hastened. The mel...Continue Reading

References

Nov 22, 1991·Brain Research·A J McArthurR A Prosser
May 3, 1990·The New England Journal of Medicine·C A CzeislerR E Kronauer
Jan 1, 1989·Chronobiology International·A Gundel, H M Wegmann
Sep 1, 1987·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C J BojkowskiJ Arendt
Jan 16, 1982·British Medical Journal·J Arendt, V Marks
Jun 1, 1983·The Journal of Clinical Endocrinology and Metabolism·A J Lewy, D A Newsome
Dec 12, 1980·Science·A J LewyS P Markey
Aug 1, 1994·Chronobiology International·P RedfernJ Waterhouse
Jun 1, 1996·Journal of Sleep Research·B MiddletonB M Stone
Mar 1, 1996·Trends in Pharmacological Sciences·S M ReppertC Godson
Nov 5, 1997·Journal of Biological Rhythms·B MiddletonB M Stone
Dec 24, 1997·Journal of Biological Rhythms·J ArendtS Deacon
Dec 23, 1999·The Journal of Endocrinology·S W LockleyJ Arendt
Feb 10, 2000·Journal of Psychopharmacology·A Doble
Oct 12, 2000·The New England Journal of Medicine·R L SackA J Lewy
Feb 13, 2001·Science·K A StokkanM Menaker
Apr 3, 2001·Medicine and Science in Sports and Exercise·D LagardeJ French
May 17, 2001·International Journal of Sports Medicine·G AtkinsonJ Waterhouse
Jun 26, 2001·Psychiatry and Clinical Neurosciences·T TakahashiK I Hayashida
Feb 9, 2002·Science·David M BersonMotoharu Takao
Dec 18, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Paul KlosenMireille Masson-Pévet
Apr 30, 2003·The Journal of Physiology·Sat Bir S KhalsaCharles A Czeisler
May 2, 2003·Nature Reviews. Cancer·Loning Fu, Cheng Chi Lee
Sep 10, 2003·Sports Medicine·Greg AtkinsonJim Waterhouse
Sep 10, 2003·Journal of Applied Physiology·M BeaumontD Lagarde
Sep 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Steven W LockleyCharles A Czeisler
Oct 11, 2003·Chronobiology International·Linda MorganJosephine Arendt
Oct 30, 2003·Journal of Biological Rhythms·Lisa M HackDebra J Skene
Aug 18, 2004·Sleep Medicine Reviews·I Haimov, J Arendt

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Citations

Jan 15, 2020·Chronobiology International·Susan LedgerStephen J Simpson
Jan 15, 2020·Drug and Therapeutics Bulletin
Apr 19, 2020·British Journal of Sports Medicine·Dina C Christa Janse van RensburgTanita Cronje
Sep 3, 2020·Journal of Biological Rhythms·Melissa E S RichardsonAmy-Claire Dauphin
Apr 13, 2019·Sports Medicine·Craig Pickering, Jozo Grgic
Mar 30, 2019·Journal of Endocrinological Investigation·G BellastellaA Bellastella
Dec 13, 2019·Pharmacological Reviews·Henry SzechtmanKurt Leroy Hoffman
Feb 17, 2021·Nature Reviews. Drug Discovery·Wei RuanHolger K Eltzschig
Jan 16, 2021·Revue neurologique·M A Quera-SalvaUNKNOWN Members of the MEL consensus group of the SFRMS
Jul 16, 2021·Sports Medicine·Dina C Janse van RensburgTanita Botha
Aug 14, 2021·Zeitschrift für Rheumatologie·K Rose, C Iking-Konert
Jul 3, 2021·Current Treatment Options in Oncology·Diwakar D BalachandranPasquale F Innominato

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Methods Mentioned

BETA
biosensor
gene knockout

Clinical Trials Mentioned

NCT00097474

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