Approaches to the solid phase of a cyclotriveratrylene scaffold-based tripodal library as potential artificial receptors

Journal of Combinatorial Chemistry
Cristina Chamorro, Rob M J Liskamp

Abstract

Two versatile tripodal cyclotriveratrylene (CTV)-based scaffolds (7 and 9) have been prepared for the solid phase construction of libraries of tripodal artificial synthetic receptors. A 2197-member library of CTV-based tripodal receptor molecules, 20[1-13,1-13,1-13], was prepared on the solid phase using split-mix synthesis. The CTV-based receptors contain three peptide arms; one of them is attached to the solid phase and is different from the other two identical peptide arms.

Citations

Jun 9, 2004·Current Opinion in Chemical Biology·Natarajan Srinivasan, Jeremy D Kilburn

Related Concepts

Technology, Pharmaceutical
Peptide Receptor
Synthetic Peptide Combinatorial Library

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