Approaches to understanding and addressing treatment-resistant depression: a scoping review.

Depression Research and Treatment
Emily Jenkins, Elliot M Goldner

Abstract

Treatment-resistant depression is associated with significant disability and, due to its high prevalence, results in substantive economic and societal burden at a population level. The objective of this study is to synthesize extant literature on approaches currently being applied to understand and address this condition. It is hoped that the findings can be used to inform practitioners and guide future research. A scoping review of the scientific literature was conducted with findings categorized and charted by underlying research paradigm. Currently, the vast majority of research stems from a biological paradigm (81%). Research on treatment-resistant depression would benefit from a broadened field of study. Given that multiple etiological mechanisms likely contribute to treatment-resistant depression and current efforts at prevention and treatment have substantial room for improvement, an expanded research agenda could more effectively address this significant public health issue.

References

Dec 1, 1993·Community Mental Health Journal·C I Cohen
Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Giovanni Andrea FavaNicoletta Sonino
Apr 23, 2003·Biological Psychiatry·Maurizio Fava
Apr 22, 2004·PharmacoEconomics·Paul GreenbergAmi Claxton
Jun 23, 2004·Journal of Affective Disorders·N Kennedy, E S Paykel
Apr 29, 2005·The Journal of Clinical Hypertension·William J Elliott, Armin Bandari
Jun 28, 2005·International Journal of Psychiatry in Medicine·Noreen Bannan
Aug 16, 2005·Urology·Sam S ChangMichael S Cookson
Sep 15, 2005·Acta Psychiatrica Scandinavica·G S MalhiP B Mitchell
May 12, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Edgar Jones
Mar 1, 2007·Pharmacopsychiatry·W SperlingS Bleich
Mar 21, 2007·Behaviour Research and Therapy·Ed WatkinsYanni Malliaris
Apr 21, 2007·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Marcelo T Berlim, Gustavo Turecki
May 25, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marcelo T Berlim, Gustavo Turecki
Sep 19, 2007·Journal of Clinical Pharmacy and Therapeutics·A F CarvalhoM C O Lima
Dec 11, 2007·Journal of Affective Disorders·Elisabeth SchrammMathias Berger
Jan 29, 2008·Current Psychiatry Reports·Diane WardenStephen R Wisniewski
Feb 12, 2008·Journal of Affective Disorders·D AmitalB Spivak
Sep 20, 2008·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Raymond W LamLakshmi N Yatham
Nov 28, 2008·Journal of Neurosurgery. Spine·Wolfgang Wagner
Feb 5, 2009·The Journal of Clinical Psychiatry·Abebaw FekaduAnthony J Cleare
Apr 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Mario F JuruenaAnthony J Cleare
Mar 17, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·L A CarvalhoC M Pariante
Mar 26, 2011·Journal of Affective Disorders·Henricus G RuhéAart H Schene

❮ Previous
Next ❯

Citations

Nov 28, 2012·Journal of Neural Transmission·Joanna Wabno, Grzegorz Hess
Nov 25, 2014·CNS Neuroscience & Therapeutics·Jian Xu, Hong Lei

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
cognitive behavioural therapy

Software Mentioned

Academic Search Premier

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.