Approaching objects cause confusion in patients with Alzheimer's disease regarding their direction of self-movement.

Brain : a Journal of Neurology
Mark Mapstone, C J Duffy

Abstract

Navigation requires real-time heading estimation based-on self-movement cues from optic flow and object motion. We presented a simulated heading discrimination task to young, middle-aged and older adult, normal, control subjects and to patients with mild cognitive impairment or Alzheimer's disease. Age-related decline and neurodegenerative disease effects were evident on a battery of neuropsychological and visual motion psychophysical measures. All subject groups made more accurate heading judgements when using optic flow patterns than when using simulated movement past earth-fixed objects. When both optic flow and congruent object were presented together, heading judgements showed intermediate accuracy. In separate trials, we combined optic flow with non-congruent object motion, simulating an independently moving object. In the case of non-congruent objects, almost all of our subjects shifted their perceived self-movement to heading in the direction of the moving object. However, patients with Alzheimer's disease uniquely indicated that perceived self-movement was straight-ahead, in the direction of visual fixation. The tendency to be confused by objects that appear to move independently in the simulated visual scene correspon...Continue Reading

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Citations

Jul 7, 2012·PloS One·Paul R MacNeilageDora E Angelaki
Oct 1, 2013·Alzheimer Disease and Associated Disorders·Thomas BenkeGeorg Kemmler
Dec 7, 2013·Survey of Ophthalmology·Radouil Tzekov, Michael Mullan
Dec 16, 2010·Vision Research·Voyko KavcicCharles J Duffy
Jul 16, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mark W AlbersLi I Zhang
Sep 11, 2014·PloS One·Michael S Jacob, Charles J Duffy
Apr 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Kalpana DokkaDora E Angelaki

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